| 2015-09-18 13:00:00September 18, 2015 | Phoenixville vs Methacton | 48 - 20 | Methacton | Recap |
| 2015-09-18 16:30:00September 18, 2015 | West Catholic vs Haverford School | 13 - 35 | Haverford School | Recap |
| 2015-09-18 18:00:00September 18, 2015 | Valley Forge Military Academy vs Academy of Palumbo | 14 - 22 | SP Super Site | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Garden Spot vs Exeter | 26 - 52 | Exeter | Recap |
| 2015-09-18 19:00:00September 18, 2015 | York Catholic vs Berks Catholic | 17 - 40 | Berks Catholic | Recap |
| 2015-09-18 19:00:00September 18, 2015 | J.P. McCaskey vs Reading | 7 - 26 | Reading | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Pottsville vs Blue Mountain | 13 - 24 | Blue Mountain | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Northern Lebanon vs Hamburg | 36 - 25 | Hamburg | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Governor Mifflin vs Manheim Township | 28 - 42 | Manheim Township | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Fleetwood vs Conrad Weiser | 41 - 59 | Fleetwood | Recap |
| 2015-09-18 19:00:00September 18, 2015 | LaSalle College Prep vs DeMatha Catholic (Md.) | 12 - 32 | Dematha Catholic (MD) | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Prep Charter vs Archbishop Wood | 8 - 49 | William Tennent | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Abington vs Upper Dublin | 14 - 63 | Upper Dublin | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Avon Grove vs Unionville | 17 - 27 | Unionville | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Bonner-Prendergast vs Academy Park | 0 - 32 | Academy Park | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Calvary Christian vs New Hope-Solebury | 6 - 21 | New Hope-Solebury | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Central Bucks West vs Pennridge | 0 - 34 | Pennridge | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Coatesville vs Roman Catholic | 24 - 3 | Roman Catholic | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Conwell-Egan vs Upper Moreland | 10 - 20 | Upper Moreland | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Council Rock North vs Pennsbury | 19 - 41 | Pennsbury | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Garnet Valley vs Ridley | 28 - 10 | Ridley | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Great Valley vs Glen Mills | 28 - 13 | Glen Mills | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Harry S. Truman vs Bensalem | 21 - 7 | Bensalem | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Kutztown vs Chichester | 0 - 51 | Chichester | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Lansdale Catholic vs Hatboro-Horsham | 45 - 20 | Hatboro-Horsham | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Marple Newtown vs Harriton | 37 - 0 | Harriton | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Neshaminy vs Council Rock South | 27 - 25 | Council Rock South | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Norristown vs Plymouth-Whitemarsh | 16 - 20 | Plymouth-Whitemarsh | Recap |
| 2015-09-18 19:00:00September 18, 2015 | North Penn vs Downingtown East | 24 - 28 | Downingtown West | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Bishop Shanahan vs William Penn Charter | 12 - 19 | William Penn Charter | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Penn Wood vs Haverford | 12 - 49 | Haverford | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Pequea vs Octorara | 22 - 6 | Octorara | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Perkiomen Valley vs Pottsgrove | 34 - 21 | Pottsgrove | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Schuylkill Valley vs Annville-Cleona | 16 - 28 | Annville-Cleona | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Twin Valley vs Daniel Boone | 33 - 38 | Daniel Boone | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Pope John Paul II vs Owen J. Roberts | 22 - 43 | Owen J. Roberts | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Quakertown vs Cheltenham | 42 - 6 | Cheltenham | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Springfield-Delco vs Radnor | 26 - 27 | Radnor | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Sun Valley vs Upper Merion | 13 - 14 | Upper Merion | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Upper Perkiomen vs Spring-Ford | 7 - 53 | Spring-Ford | Recap |
| 2015-09-18 19:00:00September 18, 2015 | West Chester East vs West Chester Rustin | 21 - 28 | West Chester Rustin | Recap |
| 2015-09-18 19:00:00September 18, 2015 | William Tennent vs Oxford | 54 - 14 | Oxford | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Wissahickon vs Souderton | 7 - 29 | Souderton | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Penncrest vs Strath Haven | 9 - 7 | Strath Haven | Recap |
| 2015-09-18 19:00:00September 18, 2015 | Sussex Central (DE) vs Interboro | 6 - 26 | Interboro | Recap |
| 2015-09-18 19:00:23September 18, 2015 | Cardinal O'Hara vs Episcopal Academy | 12 - 14 | Cardinal O'Hara | Recap |
| 2015-09-18 19:00:59September 18, 2015 | Bristol vs. Kennett | 24 - 50 | Kennett | Recap |
| 2015-09-18 19:00:59September 18, 2015 | Montclair Immaculate Conception (N.J.) vs Morrisville | 6 - 40 | Morrisville | Recap |
| 2015-09-19 01:00:05September 19, 2015 | Conestoga downs Lower Merion, 19-13 | 19 - 13 | | Recap |
| 2015-09-19 01:01:25September 19, 2015 | Upper Darby at State College | 0 - 28 | | Recap |
| 2015-09-19 01:15:55September 19, 2015 | Bishop McDevitt at Archbishop Carroll | 21 - 13 | | Recap |
| 2015-09-19 10:30:00September 19, 2015 | Father Judge vs Chester | 20 - 17 | Chester | Recap |
| 2015-09-19 11:00:00September 19, 2015 | Central Bucks South vs Central Bucks East | 27 - 40 | Central Bucks East (Youth Day) | Recap |
| 2015-09-19 13:00:00September 19, 2015 | Boyertown vs Pottstown | 14 - 28 | Pottstown | Recap |
| 2015-09-19 13:00:00September 19, 2015 | Delco Christian vs Strawberry Mansion | 47 - 25 | Strawberry Mansion | Recap |
| 2015-09-19 13:00:00September 19, 2015 | George School vs Jenkintown | 49 - 14 | Jenkintown | Recap |
| 2015-09-19 13:30:00September 19, 2015 | Muhlenberg vs Wyomissing | 0 - 35 | Wyomissing | Recap |
| 2015-09-19 13:30:37September 19, 2015 | Pennington vs Lower Moreland | 37 - 0 | Lower Moreland | Recap |
| 2015-09-19 16:00:29September 19, 2015 | Hill School vs Germantown Academy | 15 - 30 | Germantown Academy | Recap |
| 2015-09-19 18:00:00September 19, 2015 | Archbishop Ryan vs Neumann-Goretti | 34 - 18 | Neumann-Goretti | Recap |
| 2015-09-19 18:00:30September 19, 2015 | St. Ignatius (Ohio) vs St. Joseph's Prep | 6 - 35 | Plymouth-Whitemarsh | Recap |
| 2015-09-19 18:30:08September 19, 2015 | Springside-Chestnut Hill vs Mastery North Charter | 41 - 6 | | Recap |
| 2015-09-19 19:00:00September 19, 2015 | West Chester Henderson vs Solanco | 7 - 28 | Solanco | Recap |
