| 2015-11-06 15:00:00November 6, 2015 | Valley Forge Military Academy vs Calvary Christian | 21 - 35 | Calvary Christian | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Governor Mifflin vs Conrad Weiser | 23 - 20 | Conrad Weiser | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Daniel Boone vs Exeter | 3 - 42 | Exeter | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Muhlenberg vs Reading | 20 - 48 | Reading | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Fleetwood vs Kutztown | 57 - 32 | Kutztown | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Schuylkill Valley vs Hamburg | 7 - 49 | Hamburg | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Twin Valley vs ELCO | 27 - 14 | ELCO | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Bishop Shanahan vs Avon Grove | 31 - 14 | Avon Grove | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Bristol vs Lower Moreland | 50 - 13 | Lower Moreland | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Central Bucks East vs Quakertown | 24 - 23 | Quakertown | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Cheltenham vs Hatboro-Horsham | 28 - 42 | Hatboro-Horsham | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Chichester vs Glen Mills | 10 - 28 | Glen Mills | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Council Rock South vs Council Rock North | 14 - 35 | Council Rock North | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Downingtown West vs Downingtown East | 14 - 21 | Downingtown East | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Garnet Valley vs Upper Darby | 34 - 41 | Upper Darby | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Harriton vs Radnor | 13 - 49 | Radnor | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Interboro vs Academy Park | 6 - 7 | Academy Park | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Kennett vs Great Valley | 16 - 27 | Great Valley | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Lower Merion vs Haverford | 0 - 56 | Haverford | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Morrisville vs Jenkintown | 12 - 30 | Jenkintown | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Neshaminy vs Pennsbury | 16 - 14 | Pennsbury | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Octorara vs Oxford | 7 - 48 | Oxford | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Owen J. Roberts vs Boyertown | 20 - 45 | Boyertown | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Phoenixville vs Upper Perkiomen | 0 - 48 | Upper Perkiomen | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Pottstown vs Pottsgrove | 9 - 21 | Pottsgrove | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Ridley vs Conestoga | 14 - 41 | Conestoga | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Souderton vs Central Bucks South | 7 - 33 | Central Bucks South | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Springfield-Montco vs Plymouth-Whitemarsh | 0 - 56 | Plymouth-Whitemarsh | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Strath Haven vs Marple Newtown | 0 - 21 | Marple Newtown | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Sun Valley vs Unionville | 6 - 54 | Unionville | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Upper Dublin vs Upper Merion | 56 - 13 | Upper Merion | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Upper Moreland vs Wissahickon | 35 - 16 | Wissahickon | Recap |
| 2015-11-06 19:00:00November 6, 2015 | West Chester East vs West Chester Henderson | 30 - 0 | West Chester Henderson | Recap |
| 2015-11-06 19:00:00November 6, 2015 | West Chester Rustin vs Coatesville | 7 - 31 | Coatesville | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Perkiomen Valley vs Spring-Ford | 14 - 28 | Spring-Ford | Recap |
| 2015-11-06 19:00:00November 6, 2015 | Wyomissing vs Berks Catholic | 34 - 28 | Berks Catholic | Recap |
| 2015-11-06 19:00:26November 6, 2015 | William Tennent vs Central Bucks West | 6 - 32 | Central Bucks West | Recap |
| 2015-11-06 19:00:38November 6, 2015 | Pennridge vs Bensalem | 51 - 26 | Bensalem | Recap |
| 2015-11-06 19:00:52November 6, 2015 | Penncrest vs Springfield-Delco | 7 - 34 | Springfield-Delco | Recap |
| 2015-11-06 19:30:00November 6, 2015 | Abington vs North Penn | 21 - 63 | North Penn | Recap |
| 2015-11-07 13:00:00November 7, 2015 | Harry S. Truman vs Norristown | 28 - 25 | Norristown | Recap |
| 2015-11-07 13:00:00November 7, 2015 | Pope John Paul II vs Methacton | 14 - 21 | Methacton | Recap |
| 2015-11-07 13:30:17November 7, 2015 | Germantown Academy vs Haverford School | 14 - 42 | Haverford School | Recap |
| 2015-11-07 14:00:00November 7, 2015 | Chester vs Penn Wood | 14 - 34 | Penn Wood | Recap |
| 2015-11-07 14:00:29November 7, 2015 | Episcopal Academy vs Springside-Chestnut Hill | 17 - 13 | Springside-Chestnut Hill | Recap |
| 2015-11-07 15:00:12November 7, 2015 | Conwell-Egan vs Lansdale Catholic | 12 - 35 | Cardinal O'Hara | Recap |
| 2015-11-07 18:00:17November 7, 2015 | KIPP DuBois vs Bishop McDevitt | 12 - 50 | NW Super Site | Recap |
| 2015-11-07 19:00:00November 7, 2015 | New Hope-Solebury vs Delco Christian | 17 - 41 | Delco Christian | Recap |
| 2015-11-07 19:00:00November 7, 2015 | Crestwood vs Pottsville | 47 - 41 | Pottsville | Recap |
| 2015-11-07 19:00:07November 7, 2015 | Neumann-Goretti vs West Catholic | 0 - 46 | Cardinal O'Hara | Recap |
| 2015-11-07 19:00:40November 7, 2015 | William Penn Charter vs Malvern Prep | 7 - 37 | Malvern Prep | Recap |
| 2015-11-07 19:40:29November 7, 2015 | Hill School vs Lawrenceville | 26 - 28 | | Recap |
