| 2015-09-04 10:00:00September 4, 2015 | Abington vs Northeast | 14 - 21 | Northeast | Recap |
| 2015-09-04 10:00:00September 4, 2015 | Strawberry Mansion vs Jenkintown | 19 - 35 | Jenkintown | Recap |
| 2015-09-04 13:00:00September 4, 2015 | Bensalem vs Penn Wood | 0 - 20 | Penn Wood | Recap |
| 2015-09-04 15:00:00September 4, 2015 | Bristol vs Kensington | 20 - 6 | Simon Gratz | Recap |
| 2015-09-04 18:00:00September 4, 2015 | Coatesville vs Martin Luther King | 42 - 14 | NW Super Site | Recap |
| 2015-09-04 18:00:00September 4, 2015 | Conwell-Egan vs Archbishop Carroll | 6 - 0 | Wildwood NJ | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Oxford vs Solanco | 6 - 50 | Solanco | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Perkiomen Valley vs Council Rock North | 56 - 36 | Council Rock North | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Lower Merion vs Chichester | 20 - 21 | Harriton | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Conestoga vs Owen J. Roberts | 34 - 14 | Owen J. Roberts | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Philadelphia Central vs Wissahickon | 6 - 7 | Wissahickon | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Wyomissing vs Pottsville | 35 - 7 | Pottsville | Recap |
| 2015-09-04 19:00:00September 4, 2015 | ELCO vs Hamburg | 8 - 30 | Hamburg | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Council Rock South vs Pennsbury | 6 - 13 | Pennsbury | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Delaware Valley vs Upper Dublin | 7 - 42 | Upper Dublin | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Garden Spot vs Twin Valley | 47 - 13 | Twin Valley | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Archbishop Ryan vs Father Judge | 14 - 20 | Father Judge | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Schuylkill Valley vs Susquenita | 0 - 7 | Susquenita | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Downingtown East vs Frankford | 37 - 6 | Northeast | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Garnet Valley vs Unionville | 13 - 37 | Unionville | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Ridley vs Glen Mills | 30 - 0 | Ridley | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Hatboro-Horsham vs Pennridge | 29 - 55 | Pennridge | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Haverford vs Downingtown West | 3 - 41 | Downingtown West | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Marple Newtown vs Cardinal O'Hara | 34 - 7 | Cardinal O'Hara | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Mastery North Charter vs William Tennent | 19 - 31 | William Tennent | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Morrisville vs Nativity BVM | 38 - 34 | Nativity BVM | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Octorara vs Fleetwood | 41 - 46 | Fleetwood | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Reading vs William Penn | 36 - 0 | William Penn | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Academy Park vs West Chester East | 45 - 19 | West Chester East | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Avon Grove vs Kennett | 42 - 7 | Kennett | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Bonner-Prendergast vs Upper Darby | 8 - 21 | Upper Darby | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Boyertown vs Exeter | 6 - 45 | Exeter | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Central Bucks West vs Central Bucks South | 14 - 40 | Central Bucks South | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Chester vs West Chester Henderson | 6 - 14 | West Chester Henderson | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Plymouth-Whitemarsh vs Souderton | 20 - 14 | Souderton | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Pottstown vs Sun Valley | 21 - 0 | Sun Valley | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Quakertown vs Upper Perkiomen | 41 - 0 | Upper Perkiomen | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Radnor vs Upper Merion | 21 - 7 | Upper Merion | Recap |
| 2015-09-04 19:00:00September 4, 2015 | School of the Future vs New Hope-Solebury | 6 - 26 | New Hope-Solebury | Recap |
| 2015-09-04 19:00:00September 4, 2015 | State College vs Spring-Ford | 25 - 28 | Spring-Ford | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Upper Moreland vs Penncrest | 28 - 15 | Penncrest | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Susquehanna Township vs Conrad Weiser | 42 - 17 | Conrad Weiser | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Cocalico vs Daniel Boone | 0 - 7 | Daniel Boone | Recap |
| 2015-09-04 19:00:00September 4, 2015 | West Chester Rustin vs Harry S. Truman | 14 - 28 | Harry S. Truman | Recap |
| 2015-09-04 19:00:00September 4, 2015 | West Philadelphia vs Harriton | 14 - 42 | Harriton | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Wilson vs Governor Mifflin | 14 - 3 | Governor Mifflin | Recap |
| 2015-09-04 19:00:00September 4, 2015 | Muhlenberg vs Berks Catholic | 0 - 50 | Berks Catholic | Recap |
| 2015-09-04 19:00:15September 4, 2015 | Lower Moreland vs Springfield-Montco | 0 - 42 | Springfield-Montco | Recap |
| 2015-09-04 19:30:00September 4, 2015 | Prep Charter vs Strath Haven | 27 - 6 | Strath Haven | Recap |
| 2015-09-04 19:30:00September 4, 2015 | Interboro vs Springfield-Delco | 9 - 14 | Interboro | Recap |
| 2015-09-04 19:30:00September 4, 2015 | LaSalle College Prep vs North Penn | 24 - 12 | North Penn | Recap |
| 2015-09-05 00:11:32September 5, 2015 | Episcopal Academy vs. Wyoming Seminary | 48 - 14 | | Recap |
| 2015-09-05 00:50:52September 5, 2015 | St. Joseph's Prep vs. Evangel Christian | 14 - 0 | | Recap |
| 2015-09-05 11:00:00September 5, 2015 | Cheltenham vs Central Bucks East | 14 - 54 | Central Bucks East | Recap |
| 2015-09-05 11:30:00September 5, 2015 | Roman Catholic vs West Catholic | 16 - 35 | Wildwood NJ | Recap |
| 2015-09-05 13:00:00September 5, 2015 | Germantown Academy vs Bishop Shanahan | 16 - 13 | Germantown Academy | Recap |
| 2015-09-05 13:00:00September 5, 2015 | Bishop McDevitt vs Pope John Paul II | 25 - 17 | Pope John Paul II | Recap |
| 2015-09-05 13:00:00September 5, 2015 | Neshaminy vs Montclair (NJ) | 37 - 31 | Montclair | Recap |
| 2015-09-05 13:00:00September 5, 2015 | Norristown vs Methacton | 43 - 13 | Phoenixville | Recap |
| 2015-09-05 13:00:52September 5, 2015 | Washington vs Springside-Chestnut Hill | 7 - 39 | Springside-Chestnut Hill | Recap |
| 2015-09-05 13:30:32September 5, 2015 | Delaware Valley Charter vs Haverford School | 34 - 50 | | Recap |
| 2015-09-05 14:00:00September 5, 2015 | Calvary Christian vs George School | 21 - 38 | George School | Recap |
| 2015-09-05 14:00:00September 5, 2015 | Pottsgrove vs Benjamin Franklin | 21 - 27 | Simon Gratz | Recap |
| 2015-09-05 15:00:00September 5, 2015 | William Penn Charter vs Lansdale Catholic | 6 - 21 | Ocean City NJ | Recap |
| 2015-09-05 16:00:00September 5, 2015 | Valley Forge Military Academy vs Neumann-Goretti | 0 - 38 | Wildwood NJ | Recap |
| 2015-09-05 19:00:00September 5, 2015 | Kutztown vs Delco Christian | 13 - 39 | Delco Christian | Recap |
| 2015-09-05 19:00:00September 5, 2015 | Phoenixville vs Great Valley | 19 - 28 | Great Valley | Recap |
| 2015-09-05 19:00:00September 5, 2015 | Allentown (N.J.) vs Archbishop Wood | 21 - 62 | William Tennent | Recap |
