| 2021-08-27 11:00:00August 27, 2021 | Roman Catholic vs Neumann-Goretti | 18 - 22 | 2021 | South Philly Super Site | Recap |
| 2021-08-27 12:00:00August 27, 2021 | Belmont Charter vs Lower Moreland | 26 - 12 | 2021 | Lower Moreland | Recap |
| 2021-08-27 16:00:00August 27, 2021 | Pottstown vs Lower Merion | 25 - 48 | 2021 | Lower Merion | Recap |
| 2021-08-27 18:00:00August 27, 2021 | La Salle College vs Bishop McDevitt (3) | 21 - 0 | 2021 | Bishop McDevitt (3) | Recap |
| 2021-08-27 18:00:00August 27, 2021 | Lansdale Catholic vs Father Judge | 7 - 21 | 2021 | Father Judge | Recap |
| 2021-08-27 18:00:00August 27, 2021 | Archbishop Carroll vs Pope John Paul II | 14 - 43 | 2021 | Conshohocken A Field | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Bensalem vs Norristown | 28 - 20 | 2021 | Norristown | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Cheltenham vs Abington | 7 - 19 | 2021 | Abington | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Pennsbury vs Academy Park | 0 - 42 | 2021 | Academy Park | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Archbishop Ryan vs Bishop Shanahan | 3 - 21 | 2021 | Bishop Shanahan | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Plymouth-Whitemarsh vs Central Bucks South | 27 - 35 | 2021 | Central Bucks South | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Coatesville vs Central Bucks West | 35 - 14 | 2021 | Central Bucks West | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Upper Moreland vs Council Rock South | 21 - 7 | 2021 | Council Rock South | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Garnet Valley vs Downingtown West | 41 - 7 | 2021 | Downingtown West | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Chichester vs Harry S. Truman | 15 - 9 | 2021 | Harry S. Truman | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Central vs Haverford | 0 - 49 | 2021 | Haverford | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Susquehanna Township vs Kennett | 6 - 44 | 2021 | Kennett | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Souderton vs North Penn | 27 - 42 | 2021 | North Penn | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Marple Newtown vs Collingswood | 14 - 8 | 2021 | Ocean City NJ | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Downingtown East vs Pennridge | 14 - 7 | 2021 | Pennridge | Recap |
| 2021-08-27 19:00:00August 27, 2021 | William Tennent vs. Great Valley | 7 - 29 | 2021 | Great Valley | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Quakertown vs Southern Lehigh | 42 - 7 | 2021 | Southern Lehigh | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Schuylkill Valley vs Springfield-Montco | 7 - 35 | 2021 | Springfield-Montco | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Interboro vs Strath Haven | 7 - 49 | 2021 | Strath Haven | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Penncrest vs Sun Valley | 10 - 12 | 2021 | Sun Valley | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Avon Grove vs Unionville | 7 - 35 | 2021 | Unionville | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Bonner-Prendergast vs Upper Darby | 18 - 6 | 2021 | Upper Darby | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Wissahickon vs Upper Dublin | 0 - 43 | 2021 | Upper Dublin | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Fleetwood vs West Chester Henderson | 14 - 27 | 2021 | West Chester Henderson | Recap |
| 2021-08-27 19:00:00August 27, 2021 | New Hope-Solebury vs Council Rock North | 0 - 30 | 2021 | Council Rock North | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Perkiomen Valley vs Springfield-Delco | 37 - 15 | 2021 | Springfield-Delco | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Spring-Ford vs West Chester East | 44 - 0 | 2021 | West Chester East | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Owen J. Roberts vs Conestoga | 14 - 17 | 2021 | Conestoga | Recap |
| 2021-08-27 19:00:00August 27, 2021 | Harriton vs Methacton | 8 - 38 | 2021 | Methacton | Recap |
| 2021-08-27 19:00:24August 27, 2021 | Archbishop Wood vs Neshaminy | 37 - 0 | 2021 | Neshaminy | Recap |
| 2021-08-27 19:00:30August 27, 2021 | Ridley vs Central Bucks East | 34 - 29 | 2021 | Central Bucks East | Recap |
| 2021-08-27 19:00:32August 27, 2021 | Steelton-Highspire vs Morrisville | 77 - 0 | 2021 | Morrisville | Recap |
| 2021-08-27 19:00:48August 27, 2021 | Vaux Big Picture vs Bristol | 14 - 57 | 2021 | Bristol | Recap |
| 2021-08-28 09:00:00August 28, 2021 | Boyertown vs Upper Perkiomen | 35 - 12 | 2021 | Upper Perkiomen | Recap |
| 2021-08-28 11:00:00August 28, 2021 | Chester vs West Philadelphia | 34 - 6 | 2021 | West Philadelphia | Recap |
| 2021-08-28 18:00:00August 28, 2021 | Upper Merion vs Conwell-Egan | 13 - 25 | 2021 | Conwell-Egan | Recap |
| 2021-08-28 19:00:00August 28, 2021 | Wyomissing vs Daniel Boone | 41 - 14 | 2021 | Daniel Boone | Recap |
| 2021-08-29 19:00:00August 29, 2021 | Radnor vs Oxford | 22 - 25 | 2021 | Oxford | Recap |
| 2021-09-02 19:00:00September 2, 2021 | Cardinal O’Hara vs Father Judge | 7 - 42 | 2021 | Father Judge | Recap |
| 2021-09-02 19:00:00September 2, 2021 | Harriton vs Springfield-Delco | 6 - 42 | 2021 | Springfield-Delco | Recap |
| 2021-09-02 19:00:00September 2, 2021 | Kennett vs West Chester Henderson | 26 - 0 | 2021 | West Chester Henderson | Recap |
| 2021-09-02 19:00:00September 2, 2021 | Bangor vs Pottstown | 54 - 7 | 2021 | Pottstown | Recap |
| 2021-09-03 11:00:00September 3, 2021 | Boys Latin vs Penn Charter | 8 - 35 | 2021 | Penn Charter | Recap |
| 2021-09-03 12:00:00September 3, 2021 | Germantown Academy vs Simon Gratz | 48 - 18 | 2021 | Ocean City NJ | Recap |
| 2021-09-03 12:00:00September 3, 2021 | Upper Perkiomen vs Lower Moreland | 35 - 20 | 2021 | Lower Moreland | Recap |
| 2021-09-03 16:00:00September 3, 2021 | Conwell-Egan vs Interboro | 26 - 7 | 2021 | Interboro | Recap |
| 2021-09-03 16:00:02September 3, 2021 | Morrisville vs George School | 14 - 42 | 2021 | George School | Recap |
| 2021-09-03 18:00:00September 3, 2021 | La Salle College vs Malvern Prep | 10 - 7 | 2021 | Malvern Prep | Recap |
| 2021-09-03 18:00:00September 3, 2021 | Roman Catholic vs Bonner-Prendergast | 7 - 12 | 2021 | Wildwood NJ | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Penn Wood vs Avon Grove | 8 - 31 | 2021 | Avon Grove | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Hatboro-Horsham vs Bensalem | 0 - 39 | 2021 | Bensalem | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Central Bucks South vs Central Bucks West | 20 - 28 | 2021 | Central Bucks West | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Garnet Valley vs Conestoga | 55 - 14 | 2021 | Conestoga | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Haverford School vs Downingtown West | 7 - 13 | 2021 | Downingtown West | Recap |
| 2021-09-03 19:00:00September 3, 2021 | West Chester East vs Great Valley | 7 - 24 | 2021 | Great Valley | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Lower Merion vs Haverford | 28 - 42 | 2021 | Haverford | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Abington vs North Penn | 8 - 58 | 2021 | North Penn | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Sun Valley vs Oxford | 13 - 32 | 2021 | Oxford | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Radnor vs Penncrest | 35 - 7 | 2021 | Penncrest | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Pennsbury vs Pennridge | 0 - 35 | 2021 | Pennridge | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Academy of the New Church vs Springfield-Montco | 7 - 31 | 2021 | Springfield-Montco | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Downingtown East vs State College | 42 - 21 | 2021 | State College | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Marple Newtown vs Strath Haven | 13 - 41 | 2021 | Strath Haven | Recap |
| 2021-09-03 19:00:00September 3, 2021 | West Chester Rustin vs Unionville | 7 - 21 | 2021 | Unionville | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Ridley vs Upper Darby | 17 - 0 | 2021 | Upper Darby | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Academy Park vs William Tennent | 42 - 7 | 2021 | William Tennent | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Chambersburg vs Spring-Ford | 0 - 48 | 2021 | Spring-Ford | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Plymouth-Whitemarsh vs Methacton | 42 - 14 | 2021 | Methacton | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Exeter vs Boyertown | 56 - 8 | 2021 | Boyertown | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Perkiomen Valley vs Coatesville | 27 - 35 | 2021 | Coatesville | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Wissahickon vs Owen J. Roberts | 24 - 34 | 2021 | Owen J. Roberts | Recap |
| 2021-09-03 19:00:00September 3, 2021 | Daniel Boone vs Twin Valley | 10 - 19 | 2021 | Twin Valley | Recap |
| 2021-09-03 19:00:32September 3, 2021 | Central Bucks East vs. Neshaminy | 28 - 14 | 2021 | Neshaminy | Recap |
| 2021-09-04 11:00:00September 4, 2021 | Harry S. Truman vs Souderton | 0 - 41 | 2021 | Souderton | Recap |
| 2021-09-04 11:00:00September 4, 2021 | Lansdale Catholic vs Pottsgrove | 14 - 39 | 2021 | Ocean City | Recap |
| 2021-09-04 11:00:00September 4, 2021 | Upper Merion vs Norristown | 23 - 7 | 2021 | Norristown | Recap |
| 2021-09-04 12:00:00September 4, 2021 | Cheltenham vs Springside-Chestnut Hill | 14 - 38 | 2021 | Northeast | Recap |
| 2021-09-04 12:00:00September 4, 2021 | Archbishop Ryan vs Upper Moreland | 29 - 33 | 2021 | Upper Moreland | Recap |
| 2021-09-04 12:00:00September 4, 2021 | Rock Creek Christian Academy vs Archbishop Carroll | 42 - 0 | 2021 | Archbishop Carroll | Recap |
| 2021-09-04 12:00:00September 4, 2021 | Neumann-Goretti vs Archbishop Wood | 6 - 28 | 2021 | Wildwood NJ | Recap |
| 2021-09-04 13:00:00September 4, 2021 | Upper Dublin vs Council Rock South | 38 - 7 | 2021 | Council Rock South | Recap |
| 2021-09-04 13:00:00September 4, 2021 | Olney vs Chester | 0 - 26 | 2021 | Chester | Recap |
| 2021-09-04 13:00:00September 4, 2021 | New Hope-Solebury vs Pope John Paul II | 0 - 51 | 2021 | Pope John Paul II | Recap |
| 2021-09-04 13:00:00September 4, 2021 | Bishop Shanahan vs Phoenixville | 34 - 6 | 2021 | Phoenixville | Recap |
| 2021-09-04 16:00:00September 4, 2021 | Episcopal Academy vs West Catholic | 27 - 12 | 2021 | Wildwood NJ | Recap |
| 2021-09-04 18:30:03September 4, 2021 | St. Mary’s (Md.) vs St. Joseph’s Prep | 0 - 40 | 2021 | | Recap |
| 2021-09-04 19:00:00September 4, 2021 | Council Rock North vs Quakertown | 7 - 42 | 2021 | Quakertown | Recap |
| 2021-09-10 11:00:00September 10, 2021 | Norristown vs Plymouth-Whitemarsh | 8 - 49 | 2021 | Plymouth-Whitemarsh | Recap |
| 2021-09-10 18:30:00September 10, 2021 | Chester vs Martin Luther King | 18 - 6 | 2021 | Martin Luther King | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Upper Dublin vs Bensalem | 23 - 12 | 2021 | Bensalem | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Central vs Bishop Shanahan | 13 - 57 | 2021 | Bishop Shanahan | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Jenkintown vs Bristol | 6 - 31 | 2021 | Bristol | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Abington vs Central Bucks West | 0 - 21 | 2021 | Central Bucks West | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Archbishop Wood vs Cheltenham | 49 - 0 | 2021 | Cheltenham | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Berks Catholic vs Chichester | 39 - 29 | 2021 | Chichester | Recap |
| 2021-09-10 19:00:00September 10, 2021 | William Penn vs Coatesville | 44 - 39 | 2021 | Coatesville | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Penncrest vs Conestoga | 20 - 59 | 2021 | Conestoga | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Quakertown vs Council Rock South | 41 - 13 | 2021 | Council Rock South | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Delaware Valley vs Downingtown East | 14 - 39 | 2021 | Downingtown East | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Roman Catholic vs Episcopal Academy | 26 - 34 | 2021 | Episcopal Academy | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Marple Newtown vs Garnet Valley | 7 - 42 | 2021 | Garnet Valley | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Sun Valley vs Great Valley | 16 - 13 | 2021 | Great Valley | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Harry S. Truman vs Hatboro-Horsham | 42 - 0 | 2021 | Hatboro-Horsham | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Executive Education Charter vs Interboro | 6 - 43 | 2021 | Interboro | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Archbishop Carroll vs Lancaster Catholic | 19 - 21 | 2021 | Lancaster Catholic | Recap |
| 2021-09-10 19:00:00September 10, 2021 | West Catholic vs Malvern Prep | 0 - 46 | 2021 | Malvern Prep | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Conwell-Egan vs Nativity BVM | 40 - 3 | 2021 | Nativity BVM | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Kennett vs Oxford | 26 - 13 | 2021 | Oxford | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Neshaminy vs Pennridge | 14 - 28 | 2021 | Pennridge | Recap |
| 2021-09-10 19:00:00September 10, 2021 | North Penn vs Pennsbury | 35 - 0 | 2021 | Pennsbury | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Academy Park vs Reading | 41 - 6 | 2021 | Reading | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Springfield-Delco vs Ridley | 28 - 33 | 2021 | Ridley | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Council Rock North vs Souderton | 16 - 49 | 2021 | Souderton | Recap |
| 2021-09-10 19:00:00September 10, 2021 | West Chester East vs Unionville | 14 - 35 | 2021 | Unionville | Recap |
| 2021-09-10 19:00:00September 10, 2021 | West Chester Henderson vs West Chester Rustin | 14 - 42 | 2021 | West Chester Rustin | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Schuylkill Valley vs Pottsgrove | 0 - 35 | 2021 | Pottsgrove | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Downingtown West vs Perkiomen Valley | 20 - 55 | 2021 | Perkiomen Valley | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Fleetwood vs Upper Perkiomen | 41 - 0 | 2021 | Upper Perkiomen | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Avon Grove vs Owen J. Roberts | 7 - 24 | 2021 | Owen J. Roberts | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Methacton vs Wissahickon | 35 - 27 | 2021 | Wissahickon | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Daniel Boone vs Garden Spot | 45 - 17 | 2021 | Garden Spot | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Phoenixville vs Upper Moreland | 19 - 21 | 2021 | Upper Moreland | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Upper Merion vs Twin Valley | 24 - 12 | 2021 | Twin Valley | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Spring-Ford vs Cumberland Valley | 19 - 23 | 2021 | Cumberland Valley | Recap |
| 2021-09-10 19:00:00September 10, 2021 | Pottstown vs Octorara | 13 - 55 | 2021 | Octorara | Recap |
| 2021-09-11 10:30:00September 11, 2021 | Radnor vs Upper Darby | 0 - 17 | 2021 | Upper Darby | Recap |
| 2021-09-11 11:00:00September 11, 2021 | Central Bucks South vs Central Bucks East | 19 - 24 | 2021 | Central Bucks East | Recap |
| 2021-09-11 12:00:00September 11, 2021 | MIlton (GA) vs St. Joseph’s Prep | 28 - 21 | 2021 | Cardinal O'Hara | Recap |
| 2021-09-11 13:00:00September 11, 2021 | New Hope-Solebury vs Academy of the New Church | 9 - 8 | 2021 | Academy of the New Church | Recap |
| 2021-09-11 13:00:00September 11, 2021 | Lansdale Catholic vs Haverford School | 6 - 34 | 2021 | Haverford School | Recap |
| 2021-09-11 13:00:00September 11, 2021 | Imhotep Charter vs La Salle College | 8 - 13 | 2021 | La Salle College | Recap |
| 2021-09-11 13:00:00September 11, 2021 | Springside-Chestnut Hill vs Pope John Paul II | 32 - 27 | 2021 | Pope John Paul II | Recap |
| 2021-09-11 13:30:00September 11, 2021 | Boyertown vs Wyomissing | 7 - 35 | 2021 | Wyomissing | Recap |
| 2021-09-11 14:00:00September 11, 2021 | Lower Moreland vs George School | 13 - 0 | 2021 | George School | Recap |
| 2021-09-11 14:00:03September 11, 2021 | Pennington School vs Morrisville | 43 - 20 | 2021 | Morrisville | Recap |
| 2021-09-11 14:30:00September 11, 2021 | Germantown Academy vs Hill School | 12 - 0 | 2021 | Hill School | Recap |
| 2021-09-11 15:30:00September 11, 2021 | Penn Wood vs William Penn (Del.) | 8 - 27 | 2021 | William Penn (Del.) | Recap |
| 2021-09-11 19:00:00September 11, 2021 | Archbishop Ryan vs Father Judge | 21 - 14 | 2021 | Father Judge | Recap |
| 2021-09-11 19:00:00September 11, 2021 | Strath Haven vs Haverford | 49 - 35 | 2021 | Haverford | Recap |
| 2021-09-11 19:00:00September 11, 2021 | Harriton vs Lower Merion | 6 - 47 | 2021 | Lower Merion | Recap |
| 2021-09-11 19:00:00September 11, 2021 | William Tennent vs Palumbo | 19:00:007:00 pm | 2021 | Palumbo | Recap |
| 2021-09-11 19:30:00September 11, 2021 | Bonner-Prendergast vs Delaware Military Academy | 14 - 42 | 2021 | Delaware Military Academy | Recap |
| 2021-09-16 18:30:00September 16, 2021 | Archbishop Carroll vs Cardinal O’Hara | 7 - 17 | 2021 | Cardinal O'Hara | Recap |
| 2021-09-17 16:00:00September 17, 2021 | Episcopal Academy vs Hill School | 42 - 21 | 2021 | Hill School | Recap |
| 2021-09-17 16:00:00September 17, 2021 | Northeast vs Penn Charter | 16:00:004:00 pm | 2021 | Penn Charter | Recap |
| 2021-09-17 17:00:00September 17, 2021 | Pope John Paul II vs Berks Catholic | 40 - 47 | 2021 | Berks Catholic | Recap |
| 2021-09-17 18:00:00September 17, 2021 | Boys Latin vs Father Judge | 18:00:006:00 pm | 2021 | Father Judge | Recap |
| 2021-09-17 18:30:05September 17, 2021 | Morrisville vs Simon Gratz | 0 - 1 | 2021 | | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Quakertown vs Abington | 36 - 20 | 2021 | Abington | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Coatesville vs Avon Grove | 35 - 0 | 2021 | Avon Grove | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Conwell-Egan vs Bonner-Prendergast | 22 - 36 | 2021 | Bonner-Prendergast | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Hatboro-Horsham vs Central Bucks South | 8 - 50 | 2021 | Central Bucks South | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Council Rock North vs Central Bucks West | 3 - 27 | 2021 | Central Bucks West | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Bishop Shanahan vs Downingtown East | 13 - 28 | 2021 | Downingtown East | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Upper Darby vs Garnet Valley | 12 - 61 | 2021 | Garnet Valley | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Strath Haven vs Harriton | 62 - 12 | 2021 | Harriton | Recap |
| 2021-09-17 19:00:00September 17, 2021 | West Chester Rustin vs Kennett | 23 - 0 | 2021 | Kennett | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Penncrest vs Marple Newtown | 9 - 21 | 2021 | Marple Newtown | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Archbishop Ryan vs Neumann-Goretti | 7 - 14 | 2021 | Neumann-Goretti | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Plymouth-Whitemarsh vs New Hope-Solebury | 55 - 0 | 2021 | New Hope-Solebury | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Upper Dublin vs North Penn | 20 - 35 | 2021 | North Penn | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Downingtown West vs Penn Wood | 19:00:007:00 pm | 2021 | Penn Wood | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Council Rock North vs Pennridge | 0 - 35 | 2021 | Pennridge | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Harry S. Truman vs Pennsbury | 39 - 29 | 2021 | Pennsbury | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Springfield-Delco vs Radnor | 23 - 14 | 2021 | Radnor | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Haverford vs Ridley | 21 - 45 | 2021 | Ridley | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Springside-Chestnut Hill vs Roman Catholic | 19:00:007:00 pm | 2021 | Roman Catholic | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Upper Perkiomen vs Schuylkill Valley | 14 - 42 | 2021 | Schuylkill Valley | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Gonzaga (DC) vs St. Joseph’s Prep | 3 - 35 | 2021 | St. Joseph's Prep | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Unionville vs Sun Valley | 41 - 13 | 2021 | Sun Valley | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Wissahickon vs Upper Moreland | 31 - 35 | 2021 | Upper Moreland | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Oxford vs West Chester East | 21 - 14 | 2021 | West Chester East | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Great Valley vs West Chester Henderson | 14 - 38 | 2021 | West Chester Henderson | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Springfield-Montco vs William Tennent | 35 - 21 | 2021 | William Tennent | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Boyertown vs Pottsgrove | 42 - 35 | 2021 | Pottsgrove | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Methacton vs Pottstown | 14 - 7 | 2021 | Pottstown | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Manheim Central vs Perkiomen Valley | 43 - 40 | 2021 | Perkiomen Valley | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Manheim Township vs Spring-Ford | 26 - 13 | 2021 | Spring-Ford | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Octorara vs Phoenixville | 33 - 36 | 2021 | Phoenixville | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Reading vs Owen J. Roberts | 6 - 39 | 2021 | Owen J. Roberts | Recap |
| 2021-09-17 19:00:00September 17, 2021 | Norristown vs Cheltenham | 0 - 33 | 2021 | Cheltenham | Recap |
| 2021-09-17 19:00:14September 17, 2021 | Conestoga Valley vs Daniel Boone | 12 - 27 | 2021 | Daniel Boone | Recap |
| 2021-09-17 20:00:00September 17, 2021 | Haverford School vs La Salle College | 0 - 44 | 2021 | La Salle College | Recap |
| 2021-09-18 10:00:00September 18, 2021 | Conestoga vs Lower Merion | 40 - 14 | 2021 | Lower Merion | Recap |
| 2021-09-18 11:00:00September 18, 2021 | Bensalem vs Central Bucks East | 24 - 35 | 2021 | Central Bucks East | Recap |
| 2021-09-18 11:00:00September 18, 2021 | Interboro vs Chester | 27 - 28 | 2021 | Chester | Recap |
| 2021-09-18 12:00:00September 18, 2021 | Jenkintown vs Pequea Valley | 14 - 17 | 2021 | Pequea Valley | Recap |
| 2021-09-18 13:00:00September 18, 2021 | Archbishop Wood vs Malvern Prep | 0 - 21 | 2021 | Franklin Field | Recap |
| 2021-09-18 13:00:00September 18, 2021 | Olney vs Germantown Academy | 12 - 23 | 2021 | Germantown Academy | Recap |
| 2021-09-18 18:00:00September 18, 2021 | West Catholic vs Lansdale Catholic | 22 - 14 | 2021 | Wissahickon | Recap |
| 2021-09-18 19:00:53September 18, 2021 | Bristol vs Pennington School | 21 - 15 | 2021 | Pennington | Recap |
| 2021-09-20 19:00:00September 20, 2021 | Chichester vs Academy Park | 19:00:007:00 pm | 2021 | Academy Park | Recap |
| 2021-09-24 13:00:00September 24, 2021 | Upper Perkiomen vs Pope John Paul II | 0 - 49 | 2021 | Pope John Paul II | Recap |
| 2021-09-24 16:00:00September 24, 2021 | Roman Catholic vs Penn Charter | 44 - 16 | 2021 | Penn Charter | Recap |
| 2021-09-24 18:00:56September 24, 2021 | Executive Education Charter vs Bristol | 24 - 20 | 2021 | Bristol | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Central Bucks East vs Abington | 3 - 0 | 2021 | Abington | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Sun Valley vs Academy Park | 6 - 41 | 2021 | Academy Park | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Malvern Prep vs Berks Catholic | 37 - 7 | 2021 | Berks Catholic | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Pennsbury vs Central Bucks West | 14 - 42 | 2021 | Central Bucks West | Recap |
| 2021-09-24 19:00:00September 24, 2021 | West Chester Henderson vs Coatesville | 0 - 48 | 2021 | Coatesville | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Neumann-Goretti vs Conwell-Egan | 30 - 6 | 2021 | Conwell-Egan | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Hatboro-Horsham vs Council Rock North | 19:00:007:00 pm | 2021 | Council Rock North | Recap |
| 2021-09-24 19:00:00September 24, 2021 | West Chester East vs Downingtown West | 7 - 35 | 2021 | Downingtown West | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Governor Mifflin vs Episcopal Academy | 49 - 26 | 2021 | Episcopal Academy | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Avon Grove vs Great Valley | 20 - 14 | 2021 | Great Valley | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Conestoga vs Harriton | 49 - 12 | 2021 | Harriton | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Unionville vs Interboro | 20 - 19 | 2021 | Interboro | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Chichester vs Kennett | 14 - 31 | 2021 | Kennett | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Morrisville vs Lower Moreland | 12 - 27 | 2021 | Lower Moreland | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Haverford vs Marple Newtown | 16 - 49 | 2021 | Marple Newtown | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Pennridge vs North Penn | 14 - 21 | 2021 | North Penn | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Lower Merion vs Penncrest | 49 - 20 | 2021 | Penncrest | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Upper Dublin vs Quakertown | 0 - 31 | 2021 | Quakertown | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Ridley vs Radnor | 45 - 14 | 2021 | Radnor | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Council Rock South vs Souderton | 7 - 35 | 2021 | Souderton | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Upper Darby vs Springfield-Delco | 19:00:007:00 pm | 2021 | Springfield-Delco | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Plymouth-Whitemarsh vs Springfield-Montco | 35 - 14 | 2021 | Springfield-Montco | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Garnet Valley vs Strath Haven | 42 - 7 | 2021 | Strath Haven | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Cheltenham vs Upper Moreland | 32 - 21 | 2021 | Upper Moreland | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Father Judge vs William Tennent | 38 - 0 | 2021 | William Tennent | Recap |
| 2021-09-24 19:00:00September 24, 2021 | New Hope-Solebury vs Wissahickon | 7 - 43 | 2021 | Wissahickon | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Norristown vs Methacton | 13 - 21 | 2021 | Methacton | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Spring-Ford vs Perkiomen Valley | 22 - 28 | 2021 | Perkiomen Valley | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Owen J. Roberts vs Boyertown | 27 - 20 | 2021 | Boyertown | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Phoenixville vs Pottsgrove | 0 - 31 | 2021 | Pottsgrove | Recap |
| 2021-09-24 19:00:00September 24, 2021 | Upper Merion vs Pottstown | 44 - 0 | 2021 | Pottstown | Recap |
| 2021-09-25 13:00:00September 25, 2021 | Harry S. Truman vs Bensalem | 18 - 47 | 2021 | Bensalem | Recap |
| 2021-09-25 13:00:00September 25, 2021 | Rock Creek Christian Academy vs Germantown Academy | 27 - 48 | 2021 | Germantown Academy | Recap |
| 2021-09-25 13:00:00September 25, 2021 | Executive Education Charter vs Haverford School | 13:00:001:00 pm | 2021 | Haverford School | Recap |
| 2021-09-25 13:00:00September 25, 2021 | Academy of the New Church vs Jenkintown | 27 - 0 | 2021 | Jenkintown | Recap |
| 2021-09-25 13:00:00September 25, 2021 | La Salle College vs McDonogh School | 38 - 14 | 2021 | McDonogh School | Recap |
| 2021-09-25 13:00:00September 25, 2021 | Central Bucks South vs Neshaminy | 28 - 27 | 2021 | Neshaminy | Recap |
| 2021-09-25 13:00:00September 25, 2021 | St. John’s College vs Archbishop Wood | 38 - 0 | 2021 | William Tennent | Recap |
| 2021-09-25 14:00:00September 25, 2021 | Archbishop Carroll vs Archbishop Ryan | 6 - 32 | 2021 | Archbishop Ryan | Recap |
| 2021-09-25 14:30:00September 25, 2021 | Hill School vs Springside-Chestnut Hill | 35 - 21 | 2021 | Springside-Chestnut Hill | Recap |
| 2021-09-25 19:00:00September 25, 2021 | Oxford vs Chester | 21 - 38 | 2021 | Chester | Recap |
| 2021-09-25 19:00:00September 25, 2021 | West Chester Rustin vs Downingtown East | 16 - 14 | 2021 | Downingtown East | Recap |
| 2021-09-25 19:00:00September 25, 2021 | Bishop Shanahan vs Penn Wood | 49 - 8 | 2021 | Penn Wood | Recap |
| 2021-09-25 19:00:15September 25, 2021 | Daniel Boone vs Ephrata | 33 - 14 | 2021 | | Recap |
| 2021-09-25 19:30:00September 25, 2021 | Lansdale Catholic vs Cardinal O’Hara | 0 - 21 | 2021 | Cardinal O'Hara | Recap |
| 2021-10-01 13:00:00October 1, 2021 | Pottstown vs Upper Perkiomen | 0 - 29 | 2021 | Upper Perkiomen | Recap |
| 2021-10-01 18:00:00October 1, 2021 | Penn Charter vs Father Judge | 14 - 16 | 2021 | Father Judge | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Roman Catholic vs Archbishop Wood | 14 - 30 | 2021 | Archbishop Wood | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Academy Park vs Avon Grove | 8 - 14 | 2021 | Avon Grove | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Sun Valley vs Bishop Shanahan | 0 - 34 | 2021 | Bishop Shanahan | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Neumann-Goretti vs Bonner-Prendergast | 26 - 20 | 2021 | Bonner-Prendergast | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Abington vs Central Bucks South | 14 - 42 | 2021 | Central Bucks South | Recap |
| 2021-10-01 19:00:00October 1, 2021 | William Tennent vs Cheltenham | 24 - 36 | 2021 | Cheltenham | Recap |
| 2021-10-01 19:00:00October 1, 2021 | West Chester East vs Chichester | 6 - 41 | 2021 | Chichester | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Bensalem vs Council Rock North | 6 - 0 | 2021 | Council Rock North | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Unionville vs Downingtown East | 13 - 46 | 2021 | Downingtown East | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Penn Wood vs Great Valley | 21 - 48 | 2021 | Great Valley | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Upper Dublin vs Harry S. Truman | 19:00:007:00 pm | 2021 | Harry S. Truman | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Council Rock South vs Hatboro-Horsham | 48 - 13 | 2021 | Hatboro-Horsham | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Conestoga vs Haverford | 32 - 19 | 2021 | Haverford | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Downingtown West vs Kennett | 3 - 14 | 2021 | Kennett | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Upper Moreland vs New Hope-Solebury | 41 - 14 | 2021 | New Hope-Solebury | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Coatesville vs Oxford | 50 - 20 | 2021 | Oxford | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Harriton vs Penncrest | 8 - 26 | 2021 | Penncrest | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Central Bucks West vs Pennridge | 28 - 24 | 2021 | Pennridge | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Souderton vs Quakertown | 14 - 36 | 2021 | Quakertown | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Marple Newtown vs Radnor | 16 - 13 | 2021 | Radnor | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Garnet Valley vs Ridley | 65 - 37 | 2021 | Ridley | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Strath Haven vs Springfield-Delco | 17 - 14 | 2021 | Springfield-Delco | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Wissahickon vs Springfield-Montco | 6 - 14 | 2021 | Springfield-Montco | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Lower Merion vs Upper Darby | 14 - 28 | 2021 | Upper Darby | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Chester vs West Chester Henderson | 42 - 27 | 2021 | West Chester Henderson | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Interboro vs West Chester Rustin | 7 - 42 | 2021 | West Chester Rustin | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Pottsgrove vs Upper Merion | 36 - 20 | 2021 | Upper Merion | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Methacton vs Owen J. Roberts | 6 - 7 | 2021 | Owen J. Roberts | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Perkiomen Valley vs Norristown | 56 - 12 | 2021 | Norristown | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Pope John Paul II vs Phoenixville | 28 - 10 | 2021 | Phoenixville | Recap |
| 2021-10-01 19:00:00October 1, 2021 | Boyertown vs Spring-Ford | 7 - 42 | 2021 | Spring-Ford | Recap |
| 2021-10-01 19:00:03October 1, 2021 | Berks Catholic vs Daniel Boone | 40 - 7 | 2021 | Daniel Boone | Recap |
| 2021-10-02 12:00:00October 2, 2021 | Vaux Big Picture vs Lower Moreland | 12 - 41 | 2021 | Lower Moreland | Recap |
| 2021-10-02 12:00:00October 2, 2021 | Cardinal O’Hara vs West Catholic | 2 - 0 | 2021 | West Catholic | Recap |
| 2021-10-02 13:00:00October 2, 2021 | Pennsbury vs Central Bucks East | 21 - 56 | 2021 | Central Bucks East | Recap |
| 2021-10-02 13:00:00October 2, 2021 | West Philadelphia vs Germantown Academy | 13:00:001:00 pm | 2021 | Germantown Academy | Recap |
| 2021-10-02 13:00:00October 2, 2021 | George School vs Jenkintown | 14 - 17 | 2021 | Jenkintown | Recap |
| 2021-10-02 14:00:00October 2, 2021 | Bristol vs Academy of the New Church | 23 - 47 | 2021 | Academy of the New Church | Recap |
| 2021-10-02 14:30:00October 2, 2021 | Haverford School vs Landon School | 21 - 14 | 2021 | Landon School | Recap |
| 2021-10-02 15:00:00October 2, 2021 | Conwell-Egan vs Archbishop Carroll | 17 - 7 | 2021 | Archbishop Carroll | Recap |
| 2021-10-02 15:00:00October 2, 2021 | La Salle College vs St. Joseph’s Prep | 28 - 21 | 2021 | Franklin Field | Recap |
| 2021-10-02 15:00:00October 2, 2021 | Pennington School vs Hill School | 0 - 35 | 2021 | Hill School | Recap |
| 2021-10-02 19:00:00October 2, 2021 | Archbishop Ryan vs Lansdale Catholic | 34 - 21 | 2021 | Lansdale Catholic | Recap |
| 2021-10-07 19:00:00October 7, 2021 | Central Bucks South vs Council Rock South | 38 - 14 | 2021 | Council Rock South | Recap |
| 2021-10-08 15:45:00October 8, 2021 | Capital Harlem Prep vs Springside-Chestnut Hill | 6 - 35 | 2021 | Springside-Chestnut Hill | Recap |
| 2021-10-08 18:00:00October 8, 2021 | Archbishop Wood vs Father Judge | 40 - 20 | 2021 | Father Judge | Recap |
| 2021-10-08 18:30:00October 8, 2021 | Episcopal Academy vs Blair Academy | 13 - 21 | 2021 | Blair Academy | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Malvern Prep vs Archbishop Spalding (MD) | 17 - 31 | 2021 | Archbishop Spalding (MD) | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Pennridge vs Bensalem | 45 - 0 | 2021 | Bensalem | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Archbishop Carroll vs Bonner-Prendergast | 0 - 48 | 2021 | Bonner-Prendergast | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Renaissance Academy vs Bristol | 19:00:007:00 pm | 2021 | Bristol | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Strath Haven vs Conestoga | 35 - 14 | 2021 | Conestoga | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Central Bucks East vs Council Rock North | 35 - 7 | 2021 | Council Rock North | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Coatesville vs Downingtown West | 31 - 28 | 2021 | Downingtown West | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Radnor vs Garnet Valley | 0 - 41 | 2021 | Garnet Valley | Recap |
| 2021-10-08 19:00:00October 8, 2021 | North Penn vs Harry S. Truman | 48 - 20 | 2021 | Harry S. Truman | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Central Bucks West vs Hatboro-Horsham | 2 - 0 | 2021 | Hatboro-Horsham | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Springfield-Delco vs Haverford | 15 - 41 | 2021 | Haverford | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Jenkintown vs Morrisville | 19:00:007:00 pm | 2021 | Morrisville | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Springfield-Montco vs New Hope-Solebury | 41 - 14 | 2021 | New Hope-Solebury | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Great Valley vs Oxford | 14 - 21 | 2021 | Oxford | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Cheltenham vs Plymouth-Whitemarsh | 13 - 21 | 2021 | Plymouth-Whitemarsh | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Harriton vs Ridley | 6 - 70 | 2021 | Ridley | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Abington vs Souderton | 14 - 28 | 2021 | Souderton | Recap |
| 2021-10-08 19:00:00October 8, 2021 | West Chester Henderson vs Sun Valley | 21 - 14 | 2021 | Sun Valley | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Penncrest vs Upper Darby | 14 - 47 | 2021 | Upper Darby | Recap |
| 2021-10-08 19:00:00October 8, 2021 | West Chester Rustin vs West Chester East | 49 - 13 | 2021 | West Chester East | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Upper Moreland vs William Tennent | 49 - 21 | 2021 | William Tennent | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Lower Moreland vs Wissahickon | 28 - 48 | 2021 | Wissahickon | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Spring-Ford vs Norristown | 49 - 0 | 2021 | Norristown | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Methacton vs Boyertown | 11 - 42 | 2021 | Boyertown | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Pottsgrove vs Pottstown | 35 - 0 | 2021 | Pottstown | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Owen J. Roberts vs Perkiomen Valley | 7 - 49 | 2021 | Perkiomen Valley | Recap |
| 2021-10-08 19:00:00October 8, 2021 | Upper Perkiomen vs Phoenixville | 9 - 48 | 2021 | Phoenixville | Recap |
| 2021-10-08 19:00:40October 8, 2021 | Daniel Boone vs Muhlenberg | 34 - 7 | 2021 | Muhlenberg | Recap |
| 2021-10-08 19:30:00October 8, 2021 | St. Joseph’s Prep vs Middletown (DE) | 24 - 6 | 2021 | Middletown (DE) | Recap |
| 2021-10-09 10:00:00October 9, 2021 | Kennett vs Unionville | 7 - 42 | 2021 | Unionville | Recap |
| 2021-10-09 11:00:00October 9, 2021 | Penn Wood vs Chester | 6 - 39 | 2021 | Chester | Recap |
| 2021-10-09 12:00:00October 9, 2021 | Pennsbury vs Upper Dublin | 9 - 28 | 2021 | Upper Dublin | Recap |
| 2021-10-09 13:00:00October 9, 2021 | Interboro vs Chichester | 8 - 27 | 2021 | Chichester | Recap |
| 2021-10-09 13:00:00October 9, 2021 | Roman Catholic vs La Salle College | 27 - 20 | 2021 | La Salle College | Recap |
| 2021-10-09 13:00:00October 9, 2021 | Upper Merion vs Pope John Paul II | 6 - 39 | 2021 | Pope John Paul II | Recap |
| 2021-10-09 14:00:00October 9, 2021 | Penn Charter vs Lawrenceville | 13 - 7 | 2021 | Lawrenceville | Recap |
| 2021-10-09 14:00:00October 9, 2021 | Hill School vs Peddie School | 17 - 26 | 2021 | Peddie School | Recap |
| 2021-10-09 18:00:00October 9, 2021 | West Catholic vs Conwell-Egan | 0 - 36 | 2021 | Conwell-Egan | Recap |
| 2021-10-09 18:00:00October 9, 2021 | Lansdale Catholic vs Neumann-Goretti | 7 - 36 | 2021 | South Philly Super Site | Recap |
| 2021-10-09 19:00:00October 9, 2021 | Downingtown East vs Academy Park | 25 - 20 | 2021 | Academy Park | Recap |
| 2021-10-09 19:00:00October 9, 2021 | Cardinal O’Hara vs Archbishop Ryan | 3 - 14 | 2021 | Archbishop Ryan | Recap |
| 2021-10-09 19:00:00October 9, 2021 | Bishop Shanahan vs Avon Grove | 21 - 7 | 2021 | Avon Grove | Recap |
| 2021-10-09 19:00:00October 9, 2021 | Marple Newtown vs Lower Merion | 24 - 14 | 2021 | Lower Merion | Recap |
| 2021-10-15 12:00:00October 15, 2021 | Father Judge vs Roman Catholic | 21 - 20 | 2021 | Roman Catholic | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Neshaminy vs Abington | 21 - 31 | 2021 | Abington | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Downingtown West vs Bishop Shanahan | 21 - 14 | 2021 | Bishop Shanahan | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Conwell-Egan vs Cardinal O’Hara | 32 - 14 | 2021 | Cardinal O'Hara | Recap |
| 2021-10-15 19:00:00October 15, 2021 | North Penn vs Central Bucks West | 28 - 14 | 2021 | Central Bucks West | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Upper Darby vs Conestoga | 0 - 35 | 2021 | Conestoga | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Bensalem vs Council Rock South | 33 - 13 | 2021 | Council Rock South | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Avon Grove vs Downingtown East | 0 - 42 | 2021 | Downingtown East | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Germantown Academy vs Episcopal Academy | 28 - 29 | 2021 | Episcopal Academy | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Haverford vs Garnet Valley | 19:00:007:00 pm | 2021 | Garnet Valley | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Radnor vs Harriton | 19:00:007:00 pm | 2021 | Harriton | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Council Rock North vs Harry S. Truman | 19:00:007:00 pm | 2021 | Harry S. Truman | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Quakertown vs Hatboro-Horsham | 2 - 0 | 2021 | Hatboro-Horsham | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Academy Park vs Interboro | 37 - 10 | 2021 | Interboro | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Bristol vs Jenkintown | 42 - 16 | 2021 | Jenkintown | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Great Valley vs Kennett | 0 - 27 | 2021 | Kennett | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Springfield-Delco vs Marple Newtown | 7 - 18 | 2021 | Marple Newtown | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Chichester vs Penn Wood | 37 - 0 | 2021 | Penn Wood | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Central Bucks East vs Pennridge | 24 - 7 | 2021 | Pennridge | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Central Bucks South vs Pennsbury | 28 - 14 | 2021 | Pennsbury | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Penncrest vs Strath Haven | 19:00:007:00 pm | 2021 | Strath Haven | Recap |
| 2021-10-15 19:00:00October 15, 2021 | West Chester East vs Sun Valley | 19:00:007:00 pm | 2021 | Sun Valley | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Souderton vs Upper Dublin | 7 - 10 | 2021 | Upper Dublin | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Springfield-Montco vs Upper Moreland | 21 - 28 | 2021 | Upper Moreland | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Archbishop Ryan vs West Catholic | 21 - 6 | 2021 | West Catholic | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Unionville vs West Chester Henderson | 35 - 20 | 2021 | West Chester Henderson | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Oxford vs West Chester Rustin | 0 - 42 | 2021 | West Chester Rustin | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Plymouth-Whitemarsh vs William Tennent | 35 - 14 | 2021 | William Tennent | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Cheltenham vs Wissahickon | 35 - 20 | 2021 | Wissahickon | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Spring-Ford vs Methacton | 39 - 0 | 2021 | Methacton | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Perkiomen Valley vs Boyertown | 38 - 0 | 2021 | Norristown | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Phoenixville vs Upper Merion | 41 - 24 | 2021 | Upper Merion | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Upper Perkiomen vs Pottsgrove | 14 - 42 | 2021 | Pottsgrove | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Norristown vs Owen J. Roberts | 14 - 35 | 2021 | Owen J. Roberts | Recap |
| 2021-10-15 19:00:00October 15, 2021 | Pope John Paul II vs Pottstown | 28 - 0 | 2021 | Pottstown | Recap |
| 2021-10-15 19:00:09October 15, 2021 | Reading vs Daniel Boone | 0 - 35 | 2021 | | Recap |
| 2021-10-16 10:00:00October 16, 2021 | Ridley vs Lower Merion | 49 - 0 | 2021 | Lower Merion | Recap |
| 2021-10-16 11:00:00October 16, 2021 | Coatesville vs Chester | 34 - 28 | 2021 | Chester | Recap |
| 2021-10-16 12:00:00October 16, 2021 | Neumann-Goretti vs Archbishop Carroll | 54 - 0 | 2021 | Archbishop Carroll | Recap |
| 2021-10-16 13:00:00October 16, 2021 | Lower Moreland vs Academy of the New Church | 14 - 36 | 2021 | Academy of the New Church | Recap |
| 2021-10-16 13:00:00October 16, 2021 | Penn Charter vs Malvern Prep | 21 - 41 | 2021 | Malvern Prep | Recap |
| 2021-10-16 13:00:00October 16, 2021 | Haverford School vs Springside-Chestnut Hill | 31 - 28 | 2021 | Springside-Chestnut Hill | Recap |
| 2021-10-16 13:00:00October 16, 2021 | St. Joseph’s Prep vs Archbishop Wood | 38 - 20 | 2021 | William Tennent | Recap |
| 2021-10-16 14:00:00October 16, 2021 | Hun School vs Hill School | 40 - 0 | 2021 | Hill School | Recap |
| 2021-10-16 19:00:00October 16, 2021 | Bonner-Prendergast vs Lansdale Catholic | 40 - 6 | 2021 | Lansdale Catholic | Recap |
| 2021-10-22 18:00:00October 22, 2021 | La Salle College vs Father Judge | 52 - 14 | 2021 | Father Judge | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Interboro vs Avon Grove | 44 - 14 | 2021 | Avon Grove | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Quakertown vs Bensalem | 42 - 7 | 2021 | Bensalem | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Neumann-Goretti vs Cardinal O’Hara | 30 - 6 | 2021 | Cardinal O'Hara | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Pennridge vs Central Bucks South | 35 - 10 | 2021 | Central Bucks South | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Souderton vs Cheltenham | 42 - 27 | 2021 | Cheltenham | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Bishop Shanahan vs Coatesville | 20 - 32 | 2021 | Coatesville | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Lansdale Catholic vs Conwell-Egan | 0 - 12 | 2021 | Conwell-Egan | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Harry S. Truman vs Council Rock South | 13 - 20 | 2021 | Council Rock South | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Downingtown East vs Downingtown West | 27 - 21 | 2021 | Downingtown West | Recap |
| 2021-10-22 19:00:00October 22, 2021 | West Chester Rustin vs Great Valley | 42 - 0 | 2021 | Great Valley | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Upper Darby vs Harriton | 34 - 0 | 2021 | Harriton | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Renaissance Academy vs Jenkintown | 19:00:007:00 pm | 2021 | Jenkintown | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Conestoga vs Marple Newtown | 34 - 16 | 2021 | Marple Newtown | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Central Bucks West vs Neshaminy | 27 - 3 | 2021 | Neshaminy | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Central Bucks East vs North Penn | 21 - 28 | 2021 | North Penn | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Unionville vs Oxford | 49 - 22 | 2021 | Oxford | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Academy Park vs Penn Wood | 19:00:007:00 pm | 2021 | Penn Wood | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Ridley vs Penncrest | 63 - 0 | 2021 | Penncrest | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Abington vs Pennsbury | 36 - 25 | 2021 | Pennsbury | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Upper Moreland vs Plymouth-Whitemarsh | 28 - 31 | 2021 | Plymouth-Whitemarsh | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Haverford vs Radnor | 31 - 21 | 2021 | Radnor | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Garnet Valley vs Springfield-Delco | 49 - 6 | 2021 | Springfield-Delco | Recap |
| 2021-10-22 19:00:00October 22, 2021 | George School vs Springfield-Montco | 6 - 38 | 2021 | Springfield-Montco | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Roman Catholic vs St. Joseph’s Prep | 14 - 44 | 2021 | St. Joseph's Prep | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Lower Merion vs Strath Haven | 6 - 42 | 2021 | Strath Haven | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Kennett vs Sun Valley | 35 - 12 | 2021 | Sun Valley | Recap |
| 2021-10-22 19:00:00October 22, 2021 | West Chester Henderson vs West Chester East | 41 - 20 | 2021 | West Chester East | Recap |
| 2021-10-22 19:00:00October 22, 2021 | William Tennent vs Wissahickon | 22 - 36 | 2021 | Wissahickon | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Methacton vs Perkiomen Valley | 0 - 41 | 2021 | Perkiomen Valley | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Upper Merion vs Upper Perkiomen | 28 - 13 | 2021 | Upper Perkioen | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Pottstown vs Phoenixville | 7 - 41 | 2021 | Phoenixville | Recap |
| 2021-10-22 19:00:00October 22, 2021 | Boyertown vs Norristown | 28 - 33 | 2021 | Norristown | Recap |
| 2021-10-23 11:00:00October 23, 2021 | Chichester vs Chester | 14 - 0 | 2021 | Chester | Recap |
| 2021-10-23 12:00:00October 23, 2021 | Bonner-Prendergast vs Archbishop Ryan | 21 - 14 | 2021 | Archbishop Ryan | Recap |
| 2021-10-23 12:00:00October 23, 2021 | Springside-Chestnut Hill vs Germantown Academy | 15 - 37 | 2021 | Germantown Academy | Recap |
| 2021-10-23 12:00:00October 23, 2021 | Bristol vs Lower Moreland | 30 - 14 | 2021 | Lower Moreland | Recap |
| 2021-10-23 12:00:00October 23, 2021 | Episcopal Academy vs Penn Charter | 26 - 20 | 2021 | Penn Charter | Recap |
| 2021-10-23 12:00:00October 23, 2021 | Archbishop Carroll vs West Catholic | 6 - 22 | 2021 | West Catholic | Recap |
| 2021-10-23 13:00:00October 23, 2021 | Malvern Prep vs Haverford School | 24 - 13 | 2021 | Haverford School | Recap |
| 2021-10-23 13:00:00October 23, 2021 | Pottsgrove vs Pope John Paul II | 6 - 42 | 2021 | Pope John Paul II | Recap |
| 2021-10-23 13:30:00October 23, 2021 | Owen J. Roberts vs Spring-Ford | 10 - 42 | 2021 | Spring-Ford | Recap |
| 2021-10-23 16:30:00October 23, 2021 | Hill School vs Blair Academy | 27 - 46 | 2021 | Blair Academy | Recap |
| 2021-10-23 19:00:00October 23, 2021 | Upper Dublin vs Council Rock North | 40 - 0 | 2021 | Council Rock North | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Pennridge vs Abington | 27 - 7 | 2021 | Abington | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Chester vs Academy Park | 8 - 14 | 2021 | Academy Park | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Chichester vs Bishop Shanahan | 8 - 34 | 2021 | Bishop Shanahan | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Upper Merion vs Boyertown | 19 - 20 | 2021 | Boyertown | Recap |
| 2021-10-29 19:00:00October 29, 2021 | George School vs Bristol | 0 - 40 | 2021 | Bristol | Recap |
| 2021-10-29 19:00:00October 29, 2021 | North Penn vs Central Bucks South | 19:00:007:00 pm | 2021 | Central Bucks South | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Downingtown East vs Coatesville | 7 - 42 | 2021 | Coatesville | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Council Rock South vs Council Rock North | 3 - 7 | 2021 | Council Rock North | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Avon Grove vs Downingtown West | 6 - 33 | 2021 | Downingtown West | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Lower Merion vs Garnet Valley | 7 - 38 | 2021 | Garnet Valley | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Upper Dublin vs Hatboro-Horsham | 2 - 0 | 2021 | Hatboro-Horsham | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Jenkintown vs Lower Moreland | 12 - 14 | 2021 | Lower Moreland | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Germantown Academy vs Malvern Prep | 7 - 31 | 2021 | Malvern Prep | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Harriton vs Marple Newtown | 6 - 36 | 2021 | Marple Newtown | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Upper Perkiomen vs Methacton | 0 - 24 | 2021 | Methacton | Recap |
| 2021-10-29 19:00:00October 29, 2021 | William Tennent vs New Hope-Solebury | 55 - 20 | 2021 | New Hope-Solebury | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Pottstown vs Norristown | 0 - 29 | 2021 | Norristown | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Phoenixville vs Owen J. Roberts | 6 - 2 | 2021 | Owen J. Roberts | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Springfield-Delco vs Penncrest | 22 - 6 | 2021 | Penncrest | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Pope John Paul II vs Perkiomen Valley (PAC championship) | 0 - 30 | 2021 | Perkiomen Valley | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Wissahickon vs Plymouth-Whitemarsh | 7 - 54 | 2021 | Plymouth-Whitemarsh | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Harry S. Truman vs Quakertown | 6 - 50 | 2021 | Quakertown | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Strath Haven vs Radnor | 19:00:007:00 pm | 2021 | Radnor | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Conestoga vs Ridley | 28 - 29 | 2021 | Ridley | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Bensalem vs Souderton | 12 - 34 | 2021 | Souderton | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Pottsgrove vs Spring-Ford | 14 - 13 | 2021 | Spring-Ford | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Cheltenham vs Springfield-Montco | 27 - 12 | 2021 | Springfield-Montco | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Father Judge vs St. Joseph’s Prep | 13 - 21 | 2021 | St. Joseph's Prep | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Great Valley vs Unionville | 0 - 21 | 2021 | Unionville | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Upper Darby vs Upper Moreland | 36 - 6 | 2021 | Upper Moreland | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Kennett vs West Chester East | 7 - 14 | 2021 | West Chester East | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Oxford vs West Chester Henderson | 18 - 0 | 2021 | West Chester Henderson | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Sun Valley vs West Chester Rustin | 24 - 55 | 2021 | West Chester Rustin | Recap |
| 2021-10-29 19:00:00October 29, 2021 | Archbishop Wood vs La Salle College | 0 - 20 | 2021 | Wissahickon | Recap |
| 2021-10-30 12:00:00October 30, 2021 | Lansdale Catholic vs Archbishop Carroll | 13 - 7 | 2021 | Archbishop Carroll | Recap |
| 2021-10-30 12:00:00October 30, 2021 | West Catholic vs Neumann-Goretti | 6 - 40 | 2021 | South Philly Super Site | Recap |
| 2021-10-30 12:00:00October 30, 2021 | Episcopal Academy vs Springside-Chestnut Hill | 35 - 7 | 2021 | Springside-Chestnut Hill | Recap |
| 2021-10-30 13:00:00October 30, 2021 | Penn Charter vs Haverford School | 16 - 21 | 2021 | Haverford School | Recap |
| 2021-10-30 13:00:00October 30, 2021 | Jenkintown vs Lower Moreland | 12 - 14 | 2021 | Lower Moreland | Recap |
| 2021-10-30 14:00:00October 30, 2021 | Archbishop Ryan vs Conwell-Egan | 13 - 20 | 2021 | Conwell-Egan | Recap |
| 2021-10-30 14:00:00October 30, 2021 | Hill School vs Kiski School | 7 - 26 | 2021 | Kiski School | Recap |
| 2021-10-30 19:00:00October 30, 2021 | Central Bucks West vs Central Bucks East | 35 - 15 | 2021 | Central Bucks East | Recap |
| 2021-11-01 15:00:00November 1, 2021 | Cardinal O'Hara vs Bonner-Prendergast | 12 - 31 | 2021 | Bonner-Prendergast | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Malvern Prep vs Episcopal Academy | 17 - 7 | 2021 | Episcopal Academy | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Haverford vs Garnet Valley (District 1-6A first round) | 0 - 42 | 2021 | Garnet Valley | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Pennridge vs Central Bucks West (District 1-6A first round) | 17 - 19 | 2021 | Central Bucks West | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Spring-Ford vs Downingtown East (District 1-6A first round) | 14 - 21 | 2021 | Downingtown East | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Souderton vs Quakertown (District 1-6A first round) | 7 - 33 | 2021 | Quakertown | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Central Bucks South vs North Penn (District 1-6A first round) | 21 - 49 | 2021 | North Penn | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Conestoga vs Ridley (District 1-6A first round) | 23 - 42 | 2021 | Ridley | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Owen J. Roberts vs Coatesville (District 1-6A first round) | 10 - 48 | 2021 | Coatesville | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Central Bucks East vs Perkiomen Valley (District 1-6A first round) | 21 - 42 | 2021 | Perkiomen Valley | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Interboro vs West Chester Rustin (District 1-5A first round) | 17 - 34 | 2021 | West Chester Rustin | Recap |
| 2021-11-05 19:00:00November 5, 2021 | West Chester Henderson vs Upper Dublin (District 1-5A first round) | 7 - 35 | 2021 | Upper Dublin | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Cheltenham vs Plymouth-Whitemarsh (District 1-6A first round) | 0 - 49 | 2021 | Plymouth-Whitemarsh | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Upper Merion vs Strath Haven (District 1-5A first round) | 0 - 35 | 2021 | Strath Haven | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Phoenixville vs Marple Newtown (District 1-5A first round) | 14 - 21 | 2021 | Marple Newtown | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Springfield-Delco vs Unionville (District 1-5A first round) | 13 - 23 | 2021 | Unionville | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Chichester vs Bishop Shanahan (District 1-4A semifinal) | 0 - 21 | 2021 | Bishop Shanahan | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Upper Moreland vs Pottsgrove (District 1-4A semifinals) | 12 - 34 | 2021 | Pottsgrove | Recap |
| 2021-11-05 19:00:00November 5, 2021 | Boyertown vs Fleetwood (Eastern Conference Championship) | 35 - 48 | 2021 | Fleetwood | Recap |
| 2021-11-05 19:00:51November 5, 2021 | Daniel Boone vs Waynesboro (District 3-5A first round) | 20 - 42 | 2021 | | Recap |
| 2021-11-06 14:00:00November 6, 2021 | Haverford School vs Germantown Academy | 12 - 19 | 2021 | Germantown Academy | Recap |
| 2021-11-06 14:00:00November 6, 2021 | Lawrenceville vs Hill School | 6 - 10 | 2021 | Hill School | Recap |
| 2021-11-06 14:00:00November 6, 2021 | Springside-Chestnut Hill vs Penn Charter | 13 - 34 | 2021 | Penn Charter | Recap |
| 2021-11-06 14:00:00November 6, 2021 | Lower Merion vs Radnor | 14 - 33 | 2021 | Radnor | Recap |
| 2021-11-12 19:00:00November 12, 2021 | Perkiomen Valley vs Coatesville (District 1-6A quarterfinal) | 35 - 30 | 2021 | Coatesville | Recap |
| 2021-11-12 19:00:00November 12, 2021 | Pottsgrove vs Bishop Shanahan (District 1-4A championship) | 6 - 40 | 2021 | Bishop Shanahan | Recap |
| 2021-11-12 19:00:05November 12, 2021 | Marple Newtown vs Strath Haven (District 1-5A quarterfinal) | 16 - 42 | 2021 | | Recap |
| 2021-11-12 19:00:09November 12, 2021 | Quakertown vs Downingtown East (District 1-6A quarterfinal) | 42 - 21 | 2021 | | Recap |
| 2021-11-12 19:00:20November 12, 2021 | Central Bucks West vs Garnet Valley (District 1-6A quarterfinal) | 13 - 41 | 2021 | | Recap |
| 2021-11-12 19:00:25November 12, 2021 | Ridley vs North Penn (District 1-6A quarterfinal) | 56 - 55 | 2021 | | Recap |
| 2021-11-12 19:00:30November 12, 2021 | Plymouth-Whitemarsh vs Upper Dublin (District 1-5A quarterfinal) | 42 - 36 | 2021 | Wissahickon | Recap |
| 2021-11-12 19:00:42November 12, 2021 | Academy Park vs Unionville (District 1-5A quarterfinal) | 28 - 13 | 2021 | | Recap |
| 2021-11-12 19:00:53November 12, 2021 | Kennett vs West Chester Rustin (District 1-5A quarterfinal) | 21 - 41 | 2021 | | Recap |
| 2021-11-13 13:00:00November 13, 2021 | Episcopal Academy vs Haverford School | 13:00:001:00 pm | 2021 | Haverford School | Recap |
| 2021-11-13 13:00:00November 13, 2021 | Springside-Chestnut Hill vs Malvern Prep | 13:00:001:00 pm | 2021 | Malvern Prep | Recap |
| 2021-11-13 13:30:00November 13, 2021 | Germantown Academy vs Penn Charter | 13:30:001:30 pm | 2021 | Penn Charter | Recap |
| 2021-11-19 19:00:26November 19, 2021 | Academy Park vs Strath Haven (District 1-5A semifinals) | 19:00:267:00 pm | 2021 | | Recap |
| 2021-11-19 19:00:36November 19, 2021 | Ridley vs Coatesville (District 1-6A semifinals) | 19:00:367:00 pm | 2021 | | Recap |
| 2021-11-19 19:00:48November 19, 2021 | Plymouth-Whitemarsh vs West Chester Rustin (District 1-5A semifinals) | 19:00:487:00 pm | 2021 | | Recap |
| 2021-11-19 19:00:59November 19, 2021 | Quakertown vs Garnet Valley (District 1-6A semifinals) | 19:00:597:00 pm | 2021 | | Recap |
| 2021-11-24 16:00:00November 24, 2021 | Roman Catholic vs Archbishop Carroll | 16:00:004:00 pm | 2021 | Archbishop Carroll | Recap |
| 2021-11-24 18:00:00November 24, 2021 | Penncrest vs Marple Newtown | 18:00:006:00 pm | 2021 | Marple Newtown | Recap |
| 2021-11-25 10:00:00November 25, 2021 | George Washington vs Archbishop Ryan | 10:00:0010:00 am | 2021 | Archbishop Ryan | Recap |
| 2021-11-25 10:00:00November 25, 2021 | Ridley vs Interboro | 10:00:0010:00 am | 2021 | Interboro | Recap |
| 2021-11-25 10:00:00November 25, 2021 | Father Judge vs Lincoln | 10:00:0010:00 am | 2021 | Lincoln | Recap |
| 2021-11-25 10:15:00November 25, 2021 | Quakertown vs Pennridge | 10:15:0010:15 am | 2021 | Pennridge | Recap |
| 2021-11-25 10:30:00November 25, 2021 | Sun Valley vs Chichester | 10:30:0010:30 am | 2021 | Chichester | Recap |
| 2021-11-25 10:45:00November 25, 2021 | Upper Darby vs Haverford | 10:45:0010:45 am | 2021 | Haverford | Recap |
