| 2015-10-23 15:00:00October 23, 2015 | Jenkintown vs Calvary Christian | 14 - 7 | 2015 | Calvary Christian | Recap |
| 2015-10-23 15:00:00October 23, 2015 | Lower Moreland vs Valley Forge Military Academy | 20 - 14 | 2015 | Valley Forge Military Academy | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Abington vs Souderton | 41 - 42 | 2015 | Souderton | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Gettysburg vs Conrad Weiser | 0 - 47 | 2015 | Conrad Weiser | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Pottsville vs Daniel Boone | 33 - 22 | 2015 | Daniel Boone | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Exeter vs Reading | 34 - 0 | 2015 | Reading | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Muhlenberg vs Governor Mifflin | 20 - 49 | 2015 | Governor Mifflin | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Fleetwood vs Berks Catholic | 27 - 48 | 2015 | Berks Catholic | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Kutztown vs Twin Valley | 0 - 36 | 2015 | Twin Valley | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Donegal vs Schuylkill Valley | 35 - 7 | 2015 | Schuylkill Valley | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Archbishop Carroll vs Lansdale Catholic | 0 - 21 | 2015 | Wissahickon | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Avon Grove vs Coatesville | 7 - 34 | 2015 | Coatesville | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Bensalem vs Neshaminy | 8 - 41 | 2015 | Neshaminy | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Bishop Shanahan vs Downingtown East | 2 - 34 | 2015 | Downingtown East | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Central Bucks East vs Harry S. Truman | 19 - 7 | 2015 | Harry S. Truman | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Central Bucks South vs Pennridge | 17 - 28 | 2015 | Pennridge | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Council Rock North vs Central Bucks West | 33 - 15 | 2015 | Central Bucks West | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Glen Mills vs Academy Park | 0 - 33 | 2015 | Academy Park | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Great Valley vs Oxford | 34 - 14 | 2015 | Oxford | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Haverford vs Radnor | 24 - 12 | 2015 | Radnor | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Kennett vs Unionville | 7 - 42 | 2015 | Unionville | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Lower Merion vs Harriton | 41 - 20 | 2015 | Harriton | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Marple Newtown vs Garnet Valley | 17 - 40 | 2015 | Garnet Valley | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Morrisville vs New Hope-Solebury | 0 - 60 | 2015 | New Hope-Solebury | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Norristown vs William Tennent | 1 - 0 | 2015 | William Tennent | Recap |
| 2015-10-23 19:00:00October 23, 2015 | North Penn vs Pennsbury | 27 - 20 | 2015 | Pennsbury | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Octorara vs West Chester Rustin | 7 - 55 | 2015 | West Chester Rustin | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Perkiomen Valley vs Phoenixville | 42 - 0 | 2015 | Phoenixville | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Plymouth-Whitemarsh vs Hatboro-Horsham | 31 - 28 | 2015 | Hatboro-Horsham | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Pope John Paul II vs Upper Perkiomen | 10 - 38 | 2015 | Upper Perkiomen | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Pottsgrove vs Boyertown | 28 - 27 | 2015 | Boyertown | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Quakertown vs Council Rock South | 35 - 14 | 2015 | Council Rock South | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Ridley vs Penncrest | 33 - 7 | 2015 | Penncrest | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Springfield-Delco vs Conestoga | 14 - 12 | 2015 | Conestoga | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Springfield-Montco vs Upper Merion | 33 - 20 | 2015 | Upper Merion | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Sun Valley vs West Chester East | 7 - 35 | 2015 | West Chester East | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Upper Dublin vs Upper Moreland | 35 - 7 | 2015 | Upper Moreland | Recap |
| 2015-10-23 19:00:00October 23, 2015 | West Chester Henderson vs Downingtown West | 14 - 38 | 2015 | Downingtown West | Recap |
| 2015-10-23 19:00:00October 23, 2015 | Wissahickon vs Cheltenham | 14 - 30 | 2015 | Cheltenham | Recap |
| 2015-10-23 19:00:02October 23, 2015 | Archbishop Ryan vs Cardinal O'Hara | 26 - 13 | 2015 | | Recap |
| 2015-10-23 19:30:00October 23, 2015 | Upper Darby vs Strath Haven | 34 - 7 | 2015 | Strath Haven | Recap |
| 2015-10-24 10:30:00October 24, 2015 | Interboro vs Chester | 40 - 18 | 2015 | Chester | Recap |
| 2015-10-24 13:00:00October 24, 2015 | Bonner-Prendergast vs Archbishop Wood | 14 - 38 | 2015 | William Tennent | Recap |
| 2015-10-24 13:00:00October 24, 2015 | Owen J. Roberts vs Methacton | 47 - 7 | 2015 | Methacton | Recap |
| 2015-10-24 13:00:54October 24, 2015 | Springside-Chestnut Hill vs William Penn Charter | 14 - 28 | 2015 | William Penn Charter | Recap |
| 2015-10-24 13:30:00October 24, 2015 | Hamburg vs Wyomissing | 0 - 35 | 2015 | Wyomissing | Recap |
| 2015-10-24 13:30:52October 24, 2015 | Episcopal Academy vs Germantown Academy | 24 - 27 | 2015 | Germantown Academy | Recap |
| 2015-10-24 14:00:00October 24, 2015 | Chichester vs Penn Wood | 21 - 48 | 2015 | Penn Wood | Recap |
| 2015-10-24 14:00:00October 24, 2015 | Pottstown vs Spring-Ford | 0 - 34 | 2015 | Spring-Ford | Recap |
| 2015-10-24 14:00:03October 24, 2015 | Haverford School vs Malvern Prep | 31 - 14 | 2015 | | Recap |
| 2015-10-24 18:00:00October 24, 2015 | Bishop McDevitt vs Neumann-Goretti | 41 - 20 | 2015 | Neumann-Goretti | Recap |
| 2015-10-24 18:58:21October 24, 2015 | Hill School vs. Blair Academy | 27 - 58 | | | Recap |
| 2015-10-24 19:00:00October 24, 2015 | LaSalle College Prep vs Roman Catholic | 49 - 14 | 2015 | Roman Catholic | Recap |
| 2015-10-24 19:00:00October 24, 2015 | Bristol vs Delco Christian | 13 - 42 | 2015 | Delco Christian | Recap |
| 2015-10-24 19:00:00October 24, 2015 | Father Judge vs St. Joseph's Prep | 13 - 35 | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-10-25 19:00:00October 25, 2015 | West Catholic vs Conwell-Egan | 23 - 6 | 2015 | Harry S. Truman | Recap |
