| 2015-10-16 15:45:36October 16, 2015 | Penn Charter vs Haverford School | 40 - 41 | 2015 | | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Conrad Weiser vs Pottsville | 42 - 20 | 2015 | Pottsville | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Governor Mifflin vs Daniel Boone | 48 - 0 | 2015 | Daniel Boone | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Exeter vs Muhlenberg | 42 - 21 | 2015 | Muhlenberg | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Berks Catholic vs Hamburg | 42 - 14 | 2015 | Hamburg | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Wyomissing vs Fleetwood | 49 - 15 | 2015 | Fleetwood | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Reading vs Dover | 26 - 7 | 2015 | Dover | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Annville-Cleona vs Kutztown | 33 - 8 | 2015 | Kutztown | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Twin Valley vs Schuylkill Valley | 13 - 10 | 2015 | Schuylkill Valley | Recap |
| 2015-10-16 19:00:00October 16, 2015 | St. Joseph's Prep vs LaSalle College Prep | 49 - 24 | 2015 | LaSalle College Prep | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Conwell-Egan vs Lansdale Catholic | 21 - 34 | 2015 | Hatboro-Horsham | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Abington vs Central Bucks South | 25 - 34 | 2015 | Central Bucks South | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Bergen Tech (NJ) vs Morrisville | 40 - 14 | 2015 | Morrisville | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Boyertown vs Perkiomen Valley | 0 - 51 | 2015 | Perkiomen Valley | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Cheltenham vs Springfield-Montco | 26 - 7 | 2015 | Springfield-Montco | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Chester vs Glen Mills | 25 - 6 | 2015 | Glen Mills | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Conestoga vs Marple Newtown | 13 - 9 | 2015 | Marple Newtown | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Council Rock South vs William Tennent | 39 - 0 | 2015 | William Tennent | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Downingtown East vs Coatesville | 22 - 12 | 2015 | Coatesville | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Garnet Valley vs Harriton | 58 - 13 | 2015 | Harriton | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Hatboro-Horsham vs Wissahickon | 42 - 20 | 2015 | Wissahickon | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Lower Merion vs Springfield-Delco | 8 - 55 | 2015 | Springfield-Delco | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Methacton vs Pottsgrove | 7 - 51 | 2015 | Pottsgrove | Recap |
| 2015-10-16 19:00:00October 16, 2015 | North Penn vs Bensalem | 55 - 20 | 2015 | Bensalem | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Oxford vs Bishop Shanahan | 6 - 34 | 2015 | Bishop Shanahan | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Penncrest vs Haverford | 14 - 33 | 2015 | Haverford | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Pennsbury vs Pennridge | 38 - 32 | 2015 | Pennridge | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Quakertown vs Central Bucks West | 28 - 7 | 2015 | Central Bucks West | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Radnor vs Upper Darby | 7 - 33 | 2015 | Upper Darby | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Souderton vs Neshaminy | 10 - 21 | 2015 | Neshaminy | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Spring-Ford vs Owen J. Roberts | 35 - 14 | 2015 | Owen J. Roberts | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Strath Haven vs Ridley | 21 - 40 | 2015 | Ridley | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Sun Valley vs Octorara | 28 - 6 | 2015 | Octorara | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Upper Dublin vs Plymouth-Whitemarsh | 42 - 0 | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Upper Moreland vs Upper Merion | 22 - 21 | 2015 | Upper Merion | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Valley Forge Military Academy vs Jenkintown | 6 - 48 | 2015 | Jenkintown | Recap |
| 2015-10-16 19:00:00October 16, 2015 | West Chester East vs Downingtown West | 49 - 59 | 2015 | Downingtown West | Recap |
| 2015-10-16 19:00:00October 16, 2015 | West Chester Henderson vs Avon Grove | 14 - 35 | 2015 | Avon Grove | Recap |
| 2015-10-16 19:00:00October 16, 2015 | West Chester Rustin vs Kennett | 49 - 7 | 2015 | Kennett | Recap |
| 2015-10-16 19:00:00October 16, 2015 | Penn Wood vs Interboro | 28 - 47 | 2015 | Interboro | Recap |
| 2015-10-16 19:00:49October 16, 2015 | Malvern Prep vs Episcopal Academy | 33 - 14 | 2015 | | Recap |
| 2015-10-16 19:00:53October 16, 2015 | Middle Township vs. Bristol | 33 - 14 | 2015 | Bristol | Recap |
| 2015-10-16 19:30:00October 16, 2015 | Bishop McDevitt vs West Catholic | 13 - 48 | 2015 | West Catholic | Recap |
| 2015-10-17 13:00:00October 17, 2015 | Central Bucks East vs Norristown | 37 - 21 | 2015 | Norristown | Recap |
| 2015-10-17 13:00:00October 17, 2015 | New Hope-Solebury vs Lower Moreland | 55 - 8 | 2015 | Lower Moreland | Recap |
| 2015-10-17 13:00:00October 17, 2015 | Phoenixville vs Pope John Paul II | 10 - 7 | 2015 | Pope John Paul II | Recap |
| 2015-10-17 13:00:00October 17, 2015 | Upper Perkiomen vs Pottstown | 13 - 21 | 2015 | Pottstown | Recap |
| 2015-10-17 13:30:00October 17, 2015 | Harry S. Truman vs Council Rock North | 15 - 27 | 2015 | Council Rock North | Recap |
| 2015-10-17 13:30:00October 17, 2015 | Academy Park vs Chichester | 24 - 0 | 2015 | Chichester | Recap |
| 2015-10-17 13:30:40October 17, 2015 | Germantown Academy vs Springside-Chestnut Hill | 21 - 12 | 2015 | Springside-Chestnut Hill | Recap |
| 2015-10-17 14:30:00October 17, 2015 | Unionville vs Great Valley | 21 - 18 | 2015 | Great Valley | Recap |
| 2015-10-17 18:00:00October 17, 2015 | Bonner-Prendergast vs Neumann-Goretti | 20 - 14 | 2015 | Neumann-Goretti | Recap |
| 2015-10-17 19:00:00October 17, 2015 | Calvary Christian vs Delco Christian | 7 - 34 | 2015 | Delco Christian | Recap |
| 2015-10-17 19:00:00October 17, 2015 | Roman Catholic vs Father Judge | 0 - 35 | 2015 | Father Judge | Recap |
| 2015-10-17 19:00:29October 17, 2015 | Archbishop Carroll vs Archbishop Ryan | 6 - 42 | 2015 | Northeast | Recap |
| 2015-10-17 22:05:23October 17, 2015 | Hill School vs Hun School | 6 - 44 | 2015 | | Recap |
| 2015-10-18 13:00:00October 18, 2015 | Cardinal O’Hara vs Archbishop Wood | 7 - 50 | 2015 | William Tennent | Recap |
