| 2015-10-08 19:00:00October 8, 2015 | Roman Catholic vs Malvern Prep | 7 - 28 | 2015 | Malvern Prep | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Exeter vs Conrad Weiser | 35 - 20 | 2015 | Conrad Weiser | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Daniel Boone vs Reading | 7 - 61 | 2015 | Reading | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Pottsville vs Governor Mifflin | 0 - 28 | 2015 | Governor Mifflin | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Fleetwood vs Muhlenberg | 39 - 46 | 2015 | Muhlenberg | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Hamburg vs Twin Valley | 27 - 21 | 2015 | Twin Valley | Recap |
| 2015-10-09 19:00:00October 9, 2015 | West Catholic vs Neumann-Goretti | 28 - 0 | 2015 | West Catholic | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Episcopal Academy vs Conwell-Egan | 42 - 14 | 2015 | Harry S. Truman | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Central Bucks West vs Council Rock South | 15 - 50 | 2015 | Council Rock South | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Chester vs Chichester | 20 - 0 | 2015 | Chichester | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Coatesville vs West Chester East | 30 - 31 | 2015 | West Chester East | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Conestoga vs Upper Darby | 22 - 25 | 2015 | Upper Darby | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Great Valley vs West Chester Rustin | 7 - 35 | 2015 | West Chester Rustin | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Harry S. Truman vs Quakertown | 0 - 42 | 2015 | Quakertown | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Jenkintown vs Bristol | 0 - 26 | 2015 | Bristol | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Kennett vs Sun Valley | 20 - 26 | 2015 | Sun Valley | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Marple Newtown vs Springfield-Delco | 9 - 3 | 2015 | Springfield-Delco | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Methacton vs Boyertown | 13 - 38 | 2015 | Boyertown | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Neshaminy vs Central Bucks South | 21 - 14 | 2015 | Central Bucks South | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Octorara vs Avon Grove | 0 - 48 | 2015 | Avon Grove (Homecoming) | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Owen J. Roberts vs Upper Perkiomen | 37 - 6 | 2015 | Upper Perkiomen | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Oxford vs Unionville | 7 - 24 | 2015 | Unionville (Homecoming) | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Penncrest vs Radnor | 31 - 34 | 2015 | Radnor | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Pennridge vs Abington | 38 - 15 | 2015 | Abington | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Pennsbury vs Bensalem | 52 - 12 | 2015 | Bensalem | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Pope John Paul II vs Perkiomen Valley | 8 - 56 | 2015 | Perkiomen Valley | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Pottsgrove vs Spring-Ford | 13 - 22 | 2015 | Spring-Ford | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Pottstown vs Phoenixville | 20 - 0 | 2015 | Phoenixville | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Springfield-Montco vs Hatboro-Horsham | 21 - 63 | 2015 | Hatboro-Horsham | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Strath Haven vs Harriton | 68 - 14 | 2015 | Harriton | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Upper Merion vs Cheltenham | 14 - 22 | 2015 | Cheltenham | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Upper Moreland vs Plymouth-Whitemarsh | 49 - 35 | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-10-09 19:00:00October 9, 2015 | West Chester Henderson vs Downingtown East | 7 - 42 | 2015 | Downingtown East | Recap |
| 2015-10-09 19:00:00October 9, 2015 | Wissahickon vs Upper Dublin | 0 - 49 | 2015 | Upper Dublin | Recap |
| 2015-10-09 19:00:55October 9, 2015 | Archbishop Carroll vs Cardinal O'Hara | 22 - 21 | 2015 | Cardinal O'Hara | Recap |
| 2015-10-09 19:30:00October 9, 2015 | Souderton vs North Penn | 14 - 39 | 2015 | North Penn | Recap |
| 2015-10-09 19:30:00October 9, 2015 | Interboro vs Glen Mills | 31 - 0 | 2015 | Interboro | Recap |
| 2015-10-10 13:00:00October 10, 2015 | Schuylkill Valley vs Berks Catholic | 14 - 48 | 2015 | Berks Catholic | Recap |
| 2015-10-10 13:00:00October 10, 2015 | Father Judge vs Haverford School | 22 - 29 | 2015 | Haverford School | Recap |
| 2015-10-10 13:00:00October 10, 2015 | Council Rock North vs Norristown | 43 - 44 | 2015 | Norristown | Recap |
| 2015-10-10 13:00:00October 10, 2015 | Downingtown West vs Bishop Shanahan | 27 - 16 | 2015 | Bishop Shanahan | Recap |
| 2015-10-10 13:00:00October 10, 2015 | Ridley vs Lower Merion | 41 - 6 | 2015 | Lower Merion | Recap |
| 2015-10-10 13:00:00October 10, 2015 | William Tennent vs Central Bucks East | 3 - 28 | 2015 | Central Bucks East | Recap |
| 2015-10-10 13:00:14October 10, 2015 | St. Joseph's (N.J.) vs St. Joseph's Prep | 5 - 28 | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-10-10 13:30:00October 10, 2015 | New Hope-Solebury vs Academy of the New Church | 9 - 0 | 2015 | Academy of the New Church | Recap |
| 2015-10-10 14:00:00October 10, 2015 | Kutztown vs Wyomissing | 14 - 64 | 2015 | Wyomissing | Recap |
| 2015-10-10 14:00:00October 10, 2015 | Academy Park vs Penn Wood | 49 - 7 | 2015 | Penn Wood | Recap |
| 2015-10-10 15:00:00October 10, 2015 | Calvary Christian vs Morrisville | 42 - 16 | 2015 | Calvary Christian | Recap |
| 2015-10-10 15:00:00October 10, 2015 | Archbishop Ryan vs Bonner-Prendergast | 35 - 12 | 2015 | Bonner-Prendergast | Recap |
| 2015-10-10 19:00:00October 10, 2015 | Garnet Valley vs Haverford | 21 - 29 | 2015 | Garnet Valley | Recap |
| 2015-10-10 19:00:00October 10, 2015 | Lansdale Catholic vs Bishop McDevitt | 20 - 6 | 2015 | Cheltenham | Recap |
| 2015-10-10 19:00:00October 10, 2015 | Lower Moreland vs Delco Christian | 8 - 36 | 2015 | Delco Christian | Recap |
| 2015-10-10 19:00:00October 10, 2015 | Archbishop Wood vs LaSalle College Prep | 27 - 24 | 2015 | LaSalle College Prep | Recap |
