| 2015-10-02 19:00:00October 2, 2015 | Conrad Weiser vs Reading | 32 - 30 | 2015 | Reading | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Muhlenberg vs Daniel Boone | 34 - 14 | 2015 | Daniel Boone | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Exeter vs Pottsville | 24 - 7 | 2015 | Pottsville | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Lehighton vs Governor Mifflin | 7 - 6 | 2015 | Governor Mifflin | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Berks Catholic vs Twin Valley | 56 - 13 | 2015 | Twin Valley | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Hamburg vs Kutztown | 42 - 12 | 2015 | Kutztown | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Avon Grove vs West Chester East | 6 - 14 | 2015 | West Chester East | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Bensalem vs Souderton | 0 - 48 | 2015 | Souderton (Homecoming) | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Bishop Shanahan vs West Chester Henderson | 27 - 6 | 2015 | West Chester Henderson | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Central Bucks East vs Council Rock South | 26 - 32 | 2015 | Council Rock South | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Central Bucks South vs North Penn | 20 - 46 | 2015 | North Penn | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Central Bucks West vs Harry S. Truman | 27 - 0 | 2015 | Harry S. Truman | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Cheltenham vs Upper Moreland | 6 - 28 | 2015 | Upper Moreland | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Coatesville vs Downingtown West | 26 - 31 | 2015 | Downingtown West | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Harriton vs Conestoga | 8 - 49 | 2015 | Conestoga | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Norristown vs Quakertown | 7 - 49 | 2015 | Quakertown | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Octorara vs Kennett | 21 - 27 | 2015 | Kennett | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Phoenixville vs Owen J. Roberts | 10 - 21 | 2015 | Owen J. Roberts | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Plymouth-Whitemarsh vs Wissahickon | 50 - 18 | 2015 | Wissahickon | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Springfield-Delco vs Garnet Valley | 18 - 34 | 2015 | Garnet Valley | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Springfield-Montco vs Upper Dublin | 0 - 62 | 2015 | Upper Dublin | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Sun Valley vs Great Valley | 21 - 42 | 2015 | Great Valley | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Unionville vs Downingtown East | 13 - 49 | 2015 | Downingtown East | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Upper Darby vs Penncrest | 34 - 0 | 2015 | Penncrest | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Upper Merion vs Hatboro-Horsham | 6 - 30 | 2015 | Hatboro-Horsham | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Upper Perkiomen vs Pottsgrove | 6 - 47 | 2015 | Pottsgrove | Recap |
| 2015-10-02 19:00:00October 2, 2015 | Valley Forge Military Academy vs Morrisville | 14 - 0 | 2015 | Morrisville | Recap |
| 2015-10-02 19:00:00October 2, 2015 | West Chester Rustin vs Oxford | 54 - 19 | 2015 | Oxford | Recap |
| 2015-10-02 19:30:28October 2, 2015 | Malvern Prep vs St. Joseph's Prep | 33 - 21 | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-10-02 21:23:59October 2, 2015 | Interboro 23, Caravel Academy 6 | 23 - 6 | 2015 | | Recap |
| 2015-10-03 13:00:00October 3, 2015 | William Tennent vs Council Rock North | 0 - 53 | 2015 | Council Rock North | Recap |
| 2015-10-03 13:00:00October 3, 2015 | Boyertown vs Pope John Paul II | 42 - 22 | 2015 | Pope John Paul II | Recap |
| 2015-10-03 13:00:00October 3, 2015 | Calvary Christian vs Lower Moreland | 50 - 7 | 2015 | Lower Moreland | Recap |
| 2015-10-03 13:00:00October 3, 2015 | Delco Christian vs Jenkintown | 36 - 10 | 2015 | Jenkintown | Recap |
| 2015-10-03 13:00:00October 3, 2015 | Perkiomen Valley vs Pottstown | 42 - 7 | 2015 | Pottstown | Recap |
| 2015-10-03 13:00:00October 3, 2015 | Tuscarora (MD) vs Chester | 13:00:001:00 pm | 2015 | Chester | Recap |
| 2015-10-03 13:00:00October 3, 2015 | Conwell-Egan vs Neumann-Goretti | 32 - 0 | 2015 | Truman HS | Recap |
| 2015-10-03 13:30:32October 3, 2015 | Bishop McDevitt vs Germantown Academy | 6 - 41 | 2015 | Germantown Academy | Recap |
| 2015-10-03 14:00:00October 3, 2015 | Haverford School vs Penn Wood | 41 - 6 | 2015 | Penn Wood | Recap |
| 2015-10-03 14:00:00October 3, 2015 | Spring-Ford vs Methacton | 82 - 0 | 2015 | Spring-Ford | Recap |
| 2015-10-03 15:00:00October 3, 2015 | Bonner-Prendergast vs Archbishop Carroll | 7 - 6 | 2015 | Archbishop Carroll | Recap |
| 2015-10-03 15:00:00October 3, 2015 | Archbishop Ryan vs Archbishop Wood | 0 - 41 | 2015 | Washington | Recap |
| 2015-10-03 15:30:46October 3, 2015 | Lawrenceville (N.J.) vs William Penn Charter | 41 - 36 | 2015 | Conshy A Field | Recap |
| 2015-10-03 16:00:00October 3, 2015 | Lower Merion vs Marple Newtown | 0 - 40 | 2015 | Marple Newtown | Recap |
| 2015-10-03 16:00:00October 3, 2015 | West Catholic vs Lansdale Catholic | 18 - 2 | 2015 | Lansdale Catholic | Recap |
| 2015-10-03 16:00:15October 3, 2015 | Springside-Chestnut Hill vs Hill School | 23 - 20 | 2015 | | Recap |
| 2015-10-03 18:00:00October 3, 2015 | Pennridge vs Neshaminy | 17 - 7 | 2015 | Neshaminy | Recap |
| 2015-10-03 18:00:06October 3, 2015 | Academy Park vs Cardinal O'Hara | 43 - 0 | 2015 | Cardinal O'Hara | Recap |
| 2015-10-03 19:00:00October 3, 2015 | Radnor vs Ridley | 21 - 28 | 2015 | Ridley | Recap |
| 2015-10-03 19:00:00October 3, 2015 | Haverford vs Strath Haven | 47 - 20 | 2015 | Strath Haven | Recap |
| 2015-10-03 19:00:00October 3, 2015 | Schuylkill Valley vs Fleetwood | 27 - 21 | 2015 | Fleetwood | Recap |
| 2015-10-03 19:00:00October 3, 2015 | Salesianum School (DE) vs Father Judge | 7 - 14 | 2015 | Father Judge | Recap |
