| 2015-09-25 15:30:00September 25, 2015 | Delco Christian vs Valley Forge Military Academy | 41 - 13 | Bicentennial League | 2015 | Valley Forge Military Academy | Recap |
| 2015-09-25 15:30:00September 25, 2015 | Pottstown vs Pope John Paul II | 52 - 34 | PAC | 2015 | Pope John Paul II | Recap |
| 2015-09-25 16:00:23September 25, 2015 | Academy of the New Church vs Germantown Academy | 12 - 39 | Inter-Ac League | 2015 | Germantown Academy | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Calvary Christian vs Bristol | 14 - 38 | Bicentennial League | 2015 | Bristol | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Neumann-Goretti vs Cardinal O'Hara | 36 - 39 | Catholic League | 2015 | Cardinal O'Hara | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Ceasar Rodney (DE) vs Glen Mills | 44 - 22 | Del-Val League | 2015 | Glen Mills | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Daniel Boone vs Conrad Weiser | 10 - 31 | Berks Football League | 2015 | Conrad Weiser | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Susquehannock vs Exeter | 0 - 35 | Berks Football League | 2015 | Exeter | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Reading vs Governor Mifflin | 13 - 38 | Berks Football League | 2015 | Governor Mifflin | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Pottsville vs Muhlenberg | 13 - 18 | Berks Football League | 2015 | Muhlenberg | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Kutztown vs Schuylkill Valley | 13 - 14 | Berks Football League | 2015 | Schuylkill Valley | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Berks Catholic vs Columbia | 63 - 18 | Berks Football League | 2015 | Columbia | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Fleetwood vs Hamburg | 26 - 55 | Berks Football League | 2015 | Hamburg | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Central Bucks South vs Bensalem | 46 - 16 | Suburban One | 2015 | Bensalem | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Chichester vs Nativity BVM | 55 - 15 | Del-Val League | 2015 | Nativity BVM | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Downingtown East vs Avon Grove | 38 - 0 | Ches-Mont | 2015 | Avon Grove | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Great Valley vs Octorara | 47 - 0 | Ches-Mont | 2015 | Octoara | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Harriton vs Penncrest | 0 - 42 | Central League | 2015 | Penncrest | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Harry S. Truman vs Council Rock South | 15 - 50 | Suburban One | 2015 | Council Rock South | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Haverford vs Conestoga | 6 - 0 | Central League | 2015 | Conestoga | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Kennett vs Downingtown West | 20 - 61 | Ches-Mont | 2015 | Downingtown West | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Lansdale Catholic vs Academy Park | 7 - 21 | Catholic League, Del-Val League | 2015 | Academy Park | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Lower Merion vs Garnet Valley | 0 - 55 | Central League | 2015 | Garnet Valley | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Lower Moreland vs Morrisville | 10 - 7 | Bicentennial League | 2015 | Morrisville | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Methacton vs Upper Perkiomen | 21 - 31 | PAC | 2015 | Upper Perkiomen | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Norristown vs Central Bucks West | 28 - 31 | Suburban One | 2015 | Central Bucks West | Recap |
| 2015-09-25 19:00:00September 25, 2015 | North Penn vs Pennridge | 31 - 7 | Suburban One | 2015 | Pennridge | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Owen J. Roberts vs Perkiomen Valley | 14 - 49 | PAC | 2015 | Perkiomen Valley | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Oxford vs Sun Valley | 23 - 21 | Ches-Mont | 2015 | Sun Valley | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Penn Wood vs Archbishop Carroll | 8 - 30 | Catholic League, Del-Val League | 2015 | Conshy A Field | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Plymouth-Whitemarsh vs Upper Merion | 42 - 14 | Suburban One | 2015 | Upper Merion | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Pottsgrove vs Phoenixville | 42 - 7 | PAC | 2015 | Phoenixville | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Quakertown vs William Tennent | 56 - 7 | Suburban One | 2015 | William Tennent | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Radnor vs Marple Newtown | 9 - 20 | Central League | 2015 | Marple Newtown | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Ridley vs Upper Darby | 16 - 25 | Central League | 2015 | Upper Darby | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Souderton vs Pennsbury | 0 - 37 | Suburban One | 2015 | Pennsbury | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Spring-Ford vs Boyertown | 39 - 6 | PAC | 2015 | Boyertown (Hall of Fame Night) | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Strath Haven vs Springfield-Delco | 0 - 28 | Central League | 2015 | Springfield-Delco | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Unionville vs West Chester Rustin | 28 - 21 | Ches-Mont | 2015 | West Chester Rustin | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Upper Dublin vs Cheltenham | 42 - 6 | Suburban One | 2015 | Cheltenham | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Bishop Shanahan vs West Chester East | 28 - 33 | Ches-Mont | 2015 | Bishop Shanahan | Recap |
| 2015-09-25 19:00:00September 25, 2015 | West Chester Henderson vs Coatesville | 26 - 42 | Ches-Mont | 2015 | Coatesville | Recap |
| 2015-09-25 19:00:00September 25, 2015 | Jenkintown vs New Hope-Solebury | 7 - 29 | Bicentennial League | 2015 | New Hope-Solebury | Recap |
| 2015-09-25 19:00:32September 25, 2015 | Hill School vs Episcopal Academy | 18 - 23 | Inter-Ac League | 2015 | | Recap |
| 2015-09-26 10:30:00September 26, 2015 | Bonner-Prendergast vs Chester | 18 - 14 | Catholic League | 2015 | Chester | Recap |
| 2015-09-26 13:00:00September 26, 2015 | Council Rock North vs Central Bucks East | 26 - 21 | Suburban One | 2015 | Central Bucks East (Frosh Day) | Recap |
| 2015-09-26 13:00:00September 26, 2015 | Malvern Prep vs LaSalle College Prep | 14 - 21 | Catholic League, Inter-Ac League | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-09-26 13:00:00September 26, 2015 | Father Judge vs Springside-Chestnut Hill | 38 - 0 | Catholic League, Inter-Ac League | 2015 | Springside-Chestnut Hill | Recap |
| 2015-09-26 13:00:00September 26, 2015 | West Catholic vs Archbishop Wood | 6 - 48 | Catholic League | 2015 | William Tennent | Recap |
| 2015-09-26 13:00:47September 26, 2015 | Bishop McDevitt vs Steinert (N.J.) | 32 - 35 | Catholic League | 2015 | | Recap |
| 2015-09-26 13:30:00September 26, 2015 | Twin Valley vs Wyomissing | 14 - 49 | Berks Football League | 2015 | Wyomissing | Recap |
| 2015-09-26 14:00:00September 26, 2015 | Saunders Trade (NYC) vs Conwell-Egan | 0 - 35 | Catholic League | 2015 | Conwell-Egan | Recap |
