| 2015-11-13 18:00:00November 13, 2015 | Pope John Paul II vs Northampton | 18 - 47 | 2015 | Northampton | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Avon Grove vs Chichester | 6 - 0 | 2015 | Chichester (Contingency Game) | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Harriton vs Sun Valley | 0 - 34 | 2015 | Sun Valley (Contingency Game) | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Methacton vs Upper Merion | 10 - 26 | 2015 | Upper Merion | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Strawberry Mansion vs Morrisville | 20 - 19 | 2015 | Morrisville (Contingency Game) | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Hatboro-Horsham vs Owen J. Roberts | 31 - 38 | 2015 | Owen J. Roberts (Contingency Game) | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Phoenixville vs Strath Haven | 13 - 48 | 2015 | Strath Haven (Contingency Game) | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Downingtown East vs Plymouth-Whitemarsh | 35 - 28 | 2015 | Downingtown East | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Unionville vs North Penn | 7 - 48 | 2015 | Unionville | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Spring-Ford vs Neshaminy | 16 - 31 | 2015 | Spring-Ford | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Haverford vs Perkiomen Valley | 28 - 35 | 2015 | Haverford | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Upper Dublin vs Garnet Valley | 35 - 3 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Upper Darby vs Council Rock North | 59 - 34 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Academy Park vs Springfield-Delco | 14 - 7 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Great Valley vs Interboro | 17 - 8 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Upper Moreland vs Pottstown | 33 - 6 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Pottsgrove vs Marple Newtown | 7 - 20 | 2015 | Pottsgrove | Recap |
| 2015-11-13 19:00:00November 13, 2015 | New Hope-Solebury vs Lower Moreland | 27 - 0 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Springfield-Montco vs Bristol | 26 - 12 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Delco Christian vs Calvary Christian | 32 - 14 | 2015 | | Recap |
| 2015-11-13 19:00:00November 13, 2015 | Jenkintown vs Bishop McDevitt | 7 - 51 | 2015 | | Recap |
| 2015-11-13 19:00:07November 13, 2015 | Pennridge vs Ridley | 17 - 14 | 2015 | Ridley | Recap |
| 2015-11-13 19:00:16November 13, 2015 | Cheltenham vs Harry S Truman | 28 - 29 | 2015 | Harry S. Truman | Recap |
| 2015-11-13 19:30:28November 13, 2015 | Roman Catholic vs St. Joseph's Prep | 13 - 49 | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-11-14 13:00:00November 14, 2015 | Central Bucks East vs Quakertown | 6 - 7 | 2015 | | Recap |
| 2015-11-14 13:00:49November 14, 2015 | Springside-Chestnut Hill vs Malvern Prep | 20 - 46 | 2015 | Malvern Prep | Recap |
| 2015-11-14 13:30:30November 14, 2015 | Bonner-Prendergast vs Archbishop Ryan | 6 - 7 | 2015 | Northeast | Recap |
| 2015-11-14 13:30:54November 14, 2015 | Germantown Academy vs William Penn Charter | 17 - 45 | 2015 | William Penn Charter | Recap |
| 2015-11-14 14:00:00November 14, 2015 | Lower Merion vs Radnor | 14:00:002:00 pm | 2015 | Radnor (Contingency Game) | Recap |
| 2015-11-14 14:30:10November 14, 2015 | Haverford School vs Episcopal Academy | 21 - 0 | 2015 | | Recap |
| 2015-11-14 17:12:40November 14, 2015 | Lansdale Catholic vs West Catholic | 6 - 7 | 2015 | Cardinal O'Hara | Recap |
| 2015-11-14 19:00:00November 14, 2015 | Downingtown West vs Pennsbury | 28 - 35 | 2015 | Downingtown West | Recap |
| 2015-11-14 19:00:29November 14, 2015 | Father Judge vs LaSalle College Prep | 6 - 27 | 2015 | Plymouth-Whitemarsh | Recap |
| 2015-11-14 19:00:37November 14, 2015 | Archbishop Carroll vs Archbishop Wood | 6 - 49 | 2015 | William Tennent | Recap |
